Chang Gung University of Science and Technology

Nutrition and Dietitics Laboratory

Cheng-Pei Chung
https://webmis.cgust.edu.tw/Research/T_View.asp?TSn=1528

Research Field

Chemistry
Introduction

Applicant holds a post in Department of Nutrition and Health Science of Chang Gung University of Science and Technology as principal investigator. The main research focus is on physiologically active natural product from Chinese traditional medicine (CTM) and food, including the preparative procedure, analysis, isolation and purification. 

The laboratory is equipped with comprehensive instrumentation for the separation and purification of natural products. In addition, close collaboration with the  Research Center of Food and Cosmetic Safety (RCFCS) and the Center for Drug Research and Development provides a well-established platform for bioactivity screening and advanced analytical techniques. Furthermore, the laboratory maintains strong partnerships with industry, with the aim of translating fundamental research outcomes into practical industrial applications.

Research Topics

Applicant (ORCiD 0000-0002-2689-9101) focuses on the relasionship between physiological activity and TCM. Over the past five years, several herbs have been chosen as samples for investigation on chemical composition, and selected papers in recent 5 years are lested below.

  1. Lee M. Y.; Hsia S. M.; Lin C. I.; Chang Y. C.; Liang Y. H.; Chan L. C.; Lin J. T.; Chiang Y. F.; Sun W. C.; Chung C. P.* Inhibitory activity of dehulled adlay extrudate against ethanol-induced gastric mucosal injury and stability tests of active indicative components. J. Cereal Sci. 2026, 128: 104414.
  2. Chiang Y. F.†; Chung C. P.†; Huang K. C.; Li Y. P.; Hung W. L.; Hamdy N. M.; Hsia S. M. Phytochemical characterization and multi-target protective effects of Lycopodium serratum var. longipetiolatum against dysmenorrhea. Phytomedicine 2026, 152: 157838.
  3. Lin C. I.; Chang C. H.; Fan C. H.; Chiu P. C.; Tsai S. H.; Chien C. C.; Lee S. C.; Chung C. P.*; Lee M. Y.* Extraction of degraded proteins from red and green macroalgae using ultrasonic-assisted extraction and Fenton’s reagent in combination. Curr. Res. Food Sci. 2025, 10: 101085.
  4. Chiang Y. F.; Chen Y. T.; Huang K. C.; Hung W. L.; Chung C. P.; Shieh T. M.; Huang Y. L.; Ali M.; Hsia S. M. Protective effects of l-cysteine against cisplatin-induced reproductive damage in male rats. Antioxidants (Basel) 2024, 13(12): 1443.
  5. Lin Y. W.; Lee T. M.; Chung C. P.; Tsai Y. C.; Huang D. W.; Huang P. H. Growth of Cordyceps militaris cultivation and its bioactive component accumulation as affected by various single-wavelength light-emitting diodes (LED) light sources. Int. J. Food Prop. 2024, 27(1): 897-908.
  6. Tsai S. H.; Fan C. H.; Chung C. P.; Lu S. T.; Lee M. Y. Extraction of pectin from jelly fig shell using microwave heating extraction: Pectin physicochemical properties and antioxidant activities. Int. J. Food Eng. 2024, 20(3): 201-215.
  7. Tsai S. H.; Fan C. H.; Chung C. P.; Lin H. W.; Lee M. Y. Modification and texturization of plant proteins for vegetarian shrimp applications using transglutaminase. J. Agric. Food Res. 2024, 16: 101064.
  8. Chung C. P.; Tsai S. H.; Fan C. H.; Hung L. H.; Chien C. C.; Lee M. Y. Microwave- and ultrasound-assisted extraction of pectin yield and physicochemical properties from lemon peel. J. Agric. Food Res. 2024, 15: 101009.
  9. Lin H. Y.†; Chung C. P.†; Hsia S. M.; Chang Y. C.; Chaing W.; Kuo Y. H.; Lin Y. L. Anti-inflammatory alkaloids from lotus (Nelumbo nucifera Gaertn.) leaves. Eur. Food Res. Technol. 2023, 249(3): 739-748.
  10. Chiang Y. F.; Huang K. C.; Chen H. Y.; Huang T. C.; Ali M.; Chang H. Y.; Shieh T. M.; Shih Y. H.; Wang K. L.; Huang Y. J.; Chung C. P.; Hsia S. M. The adipokine visfatin modulates cancer stem cell properties in triple-negative breast cancer. Biomedicines 2023, 11(2): 297.
  11. Chung C. P.†; Hsia S. M.†; Chang W. S.; Huang D. W.; Chiang W.; Ali M.; Lee M. Y.; Wu C. H. Antiglycation effects of adlay seed and its active polyphenol compounds: An in vitro study. Molecules 2022, 27(19): 6729.
  12. Chiang Y. F.†; Chung C. P.†; Lin J. H.; Chiang W.; Chen H. Y.; Ali M.; Shih Y. H.; Wang K. L.; Huang T. C.; Chang H. Y.; Lin L. C.; Shieh T. M.; Hsia S. M. Adlay seed (Coix lacryma-jobi L. var. ma-yuen Stapf.) ethanolic extract fractions and subfractions induce cell cycle arrest and apoptosis in human breast and cervical cancer cell lines. Molecules2022, 27(13): 3984.
  13. Hsu W. H.; Chung C. P.; Wang Y. Y.; Kuo Y. H.; Yeh C. H.; Lee I. J.; Lin Y. L. Dendrobium nobile protects retinal cells from UV-induced oxidative stress damage via Nrf2/HO-1 and MAPK pathways. J. Ethnopharmacol. 2022, 288: 114886.
  14. Chung C. P.; Lee M. Y.; Hsia S. M.; Chiang W.; Kuo Y. H.; Hsu H. Y.; Lin Y. L. Suppression on allergic airway inflammation of dehulled adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) in mice and anti-degranulation phytosterols from adlay bran. Food Funct. 2021, 12(24): 12788-12799. 
  15. Huang Y. J.; Chen Y. C.; Chen H. Y.; Chiang Y. F.; Ali M.; Chiang W.; Chung C. P.; Hsia S. M. Ethanolic extracts of adlay testa and hull and their active biomolecules exert relaxing effect on uterine muscle contraction through blocking extracellular calcium influx in ex vivo and in vivo studies. Biomolecules 2021, 11(6): 887.
Honor
  1. Yi-Fen Chiang, Ko-Chieh Huang, Cheng-Pei Chung, Shih-Min Hsia. Exploring the therapeutic role of hinokitiol in uterine leiomyoma proliferation and ECM accumulation. The 54th Annual Member Meeting and Conference of the Taiwan Association for Food Science and Technology. Excellence Award. 2024.
  2. 2023 Academic Year Teaching Excellence Award, Chang Gung University of Science and Technology.
  3. Jia-Yun Li, Ling Hu1, Yu-Chia Chang, Huei-Tzu Chien, Chun-Hui Chiu, Yu-Tsung Lee, Shih-Min Hsia, Ming-Yi Lee, Cheng-Pei Chung. Anti-inflammatory activity of Polygonum hydropiper and the chemical composition of active partitioned fraction. 2023 Annual Meeting and Scientific Symposium of the Society for Free Radical and Medicine Research - Taiwan (SFRR-Taiwan). Best Poster Award. 2023.
  4. 楊巧敏、廖于君、謝雨璇、陳于晴、蔡岳庭、鄭怡欣、莊培梃、蔣昭弘、李明怡*、鍾成沛*。消費者對有機食品之看法與現行認證制度改善方針。110學年度長庚科技大學保健營養系專題研究論文發表與競賽活動。佳作。2022。
  5. 方怡雯、許家珊、王沛筑、周郁辰、許詠婷、鍾成沛*、羅鈺琁*。菓然檬商品包裝及行銷。中華科技大學健康科技學院107學年度學生實務專題製作競賽。第三名。2019。
  6. 鍾成沛、夏詩閔、林雲蓮、江文章、李明怡。薏苡麩皮化學成分對人類婦癌細胞之存活率影響。2017長庚保健盃全國健康餐飲實務技能競賽。佳作。2017。
  7. 徐志杰、詹婉柔、黃怡嘉、賴群鈦、孫鈺茹、林佩璇、杜芹、鍾成沛*。彩色乾燥麵體之製程研製及物性變化。中華科技大學健康科技學院106學年度學生實務專題製作競賽。佳作。2017。
  8. 鍾成沛、顏翌茹、魏莉雯、林昱文。波動金線連咖啡－複頻超音波輔助萃取金線連的應用。中華科技大學健康科技學院105學年度學生實務專題製作競賽，第二名。2016。
  9. 鍾成沛、林昱文、王彥晴、林奕辰、施欣妤、張書妍。波動跳出好料理－超音波調理機。第三屆全國餐旅IDEA創意設計大賽，第一名。2015。
Educational Background
  1. Doctorial and Master Degree: Institute of Food Science and Technology, National Taiwan University 
  2. Bachelor’s degree: Department of Food Science, National Taiwan Ocean University

Job Description

  1. To establish the optimized extracting conditions by response surface methodology (RSM), and to prepare partial-purified extract of  Marsilea minuta L. (MME).
  2. To analysis the chemical composition of MME, and further to isolate and purify compounds within MME.
  3. To evaluate the physiological impact of MME by network pharmacology and molecular docking.

Preferred Intern Educational Level

university undergraduates/graduates and/or master/Ph. D. students

 

Skill sets or Qualities

  1. column chromatography
  2. preparative HPLC
  3. 1D/2D NMR
  4. mass spectrometer
  5. online network pharmacology/molecular docking software