Yeast Lab.
Research Field
I have been teaching at National Changhua University of Education in the Department of Biology for twelve years. The management style of my laboratory tends toward the American approach, where students are required to have their own ideas to design experiments. Consequently, the experimental themes undertaken by different students are not entirely identical. Students are expected to manage their own time for experiments daily, yet they must report progress to me every week, detailing the progress of the previous week's experiments and outlining the experiments to be conducted in the coming week. In my laboratory, whether students are Taiwanese or international, lab meetings are conducted in English. Therefore, I prefer to mentor students who are outgoing and possess basic English proficiency.
Currently, our laboratory comprises more than 10 students (including six international students) and several foreign interns (participating in the TAIWAN EXPERIENCE EDUCATION PROGRAM). This diversity makes our laboratory environment highly conducive for both foreign students and scholars interested in conducting short-term or long-term research. With the generous support of the TAIWAN EXPERIENCE EDUCATION PROGRAM, we have successfully recruited more than 20 foreign students over the past two years for six-month short-term research programs in Taiwan. Remarkably, one of these students has advanced to pursue a doctoral degree and currently serves as a postdoctoral researcher within our department. Additionally, two students have opted to remain in Taiwan to pursue master's degrees. Over the past two years, Taiwanese students have adeptly adapted to interacting and collaborating with their foreign counterparts on various research endeavors.
The laboratory currently focuses on microbiology-related topics, encompassing the ecology, evolution, and applications of microorganisms. For the upcoming IIPP program under the NSTC application, the proposed experimental theme includes two key projects. Details are outlined in the following abstracts:
Project 1: Investigating Pathogen Transmission in Shiitake Mushrooms
Shiitake mushrooms (Lentinula edodes), the second most widely consumed mushroom globally, face significant challenges from spontaneous productivity losses, adversely impacting the agricultural sector. Despite various proposed causes—such as genetic degeneration, suboptimal culture conditions, climate change, and pathogenic infections—no single factor has been definitively identified as the root cause. This project aims to investigate the role of pathogens, particularly focusing on slime molds as potential carriers of these pathogens.
While insect carriers have been extensively studied, slime molds, which are ubiquitous in mushroom farms, remain largely overlooked in pathogen transmission research. The objectives of this study include identifying pathogens (bacteria, fungi, and mycoviruses) affecting shiitake mushrooms, assessing the seasonal diversity and prevalence of slime molds, and evaluating their potential role as pathogen vectors.
By examining the interactions between environmental factors, slime molds, and pathogen dynamics, this research will provide an ecological perspective on managing pathogen transmission. The findings aim to offer practical strategies for reducing productivity losses, benefiting farmers economically while ensuring a stable supply of this nutritious food. By pioneering the study of slime molds as pathogen carriers, this project could revolutionize pathogen management strategies in mushroom farming, contributing to global food security.
Project 2: Exploring Host-Microbe Interactions in Physarum polycephalum
This project investigates the intricate interactions between the slime mold Physarum polycephalum and its associated microbial communities, with the goal of elucidating co-evolutionary dynamics within this symbiotic system. The study will explore how microbial endosymbionts adapt to host influences—via resistance, escape, or exploitation—and how P. polycephalum manipulates these microbes to optimize mutualistic, commensalistic, or parasitic relationships.
By analyzing samples from diverse regions in Taiwan and worldwide, the research will identify the core microbiota of P. polycephalum, characterizing their ecological roles and their impact on host fitness. Microbiome analysis, genomic sequencing, and ecological assessments will be employed to investigate the physiological and genomic differences between symbiotic microbes in host environments and their free-living counterparts.
Additionally, the study will examine mechanisms of horizontal microbial transfer, host specificity, and potential inter-strain or inter-species exchanges. These findings will provide insights into the plasticity of microbial symbiosis and host-microbe co-adaptation in simple eukaryotic systems. The outcomes may have broader implications for microbial evolution and applications in biotechnology, medicine, and environmental science, including the discovery of novel bioactive compounds.
Received Flexible Salary Awards from the Ministry of Science and Technology and the Ministry of Education:
Granted the Special Outstanding Talent Recruitment Incentive Award from the Ministry of Science and Technology in 2013.
Awarded the Special Outstanding Talent Recruitment Incentive Award from the Ministry of Science and Technology in 2014.
Recognized with the Special Outstanding Talent Incentive Award from the Ministry of Science and Technology in 2015.
Received the Special Outstanding Talent Incentive Award for Higher Education Institutions from the Ministry of Science and Technology in 2017.
Granted the Research Incentive Award from the Ministry of Science and Technology in 2018.
Received the Research Incentive Award from the Ministry of Science and Technology in 2019.
Awarded the Research Incentive Award from the Ministry of Science and Technology in 2020.
Recognized with the Research Incentive Award from the Ministry of Science and Technology in 2021.
Also, received internal research awards:
Top Research Award for Faculty Research Achievements in 2021.
Top Research Award for Faculty Research Achievements in 2018.
Newcomer Model Award for Faculty Research Achievements in 2018.
Outstanding Teaching Faculty in 2018.
Award for Executing Two or More Projects from the Ministry of Science and Technology in 2018.
Academic Research Award from the Baisha Cultural and Educational Foundation in 2019.
Academic Research Award from the Baisha Cultural and Educational Foundation in 2015.
Faculty Research Achievement Award from National Changhua University of Education in 2021.
Faculty Research Achievement Award from National Changhua University of Education in 2020.
Faculty Research Achievement Award from National Changhua University of Education in 2019.
Faculty Research Achievement Award from National Changhua University of Education in 2018.
Faculty Research Achievement Award from National Changhua University of Education in 2017.
Faculty Research Achievement Award from National Changhua University of Education in 2016.
Faculty Research Achievement Award from National Changhua University of Education in 2015.
Faculty Research Achievement Award from National Changhua University of Education in 2014.
Outstanding Mentor from National Changhua University of Education in 2015.
Distinguished Mentor from National Changhua University of Education in 2014.
Outstanding Award for Industry-Academia Cooperation in 2018.
I obtained my bachelor's and master's degrees from National Changhua University of Education, Taiwan. Subsequently, I earned my Ph.D. degree from National Yang Ming Chiao Tung University, Taiwan. Following that, I pursued my Postdoctoral Fellowship at Harvard Medical School, USA.
Job Description
Project 2: Exploring Host-Microbe Interactions in Physarum polycephalum
1. Research Overview This project investigates the intricate interactions between the slime mold Physarum polycephalum and its associated microbial communities, aiming to elucidate the co-evolutionary dynamics within this unique symbiotic system. We will explore how microbial endosymbionts adapt to host influences—whether through resistance, escape, or exploitation—and how P. polycephalum actively manipulates these microbes to optimize mutualistic, commensalistic, or parasitic relationships. By utilizing samples collected from diverse regions in Taiwan and worldwide, we aim to identify the core microbiota of P. polycephalum, characterizing their ecological roles and impact on host fitness. The study employs advanced microbiome analysis, genomic sequencing, and ecological assessments to investigate physiological and genomic distinctions between symbiotic and free-living microbes. Ultimately, this research offers broader implications for microbial evolution and applications in biotechnology and medicine, including the potential discovery of novel bioactive compounds.
2. Candidate Requirements & Expectations Our laboratory fosters an American management style, emphasizing intellectual independence and active engagement. We are seeking an excellent student who meets the following criteria:
Hands-on Experience (Priority):
Microbial Manipulation: Candidates with prior experience in general microbiology (e.g., handling bacteria, fungi, or other microorganisms) are our top priority.
Note: Specific experience with slime molds is NOT required. However, proficiency in aseptic techniques, microbial culturing, and basic molecular biology protocols is essential to successfully handle the experiments.
Work Style (Independence):
Independent Researcher: Students are expected to propose their own ideas and design experiments independently. You must be self-disciplined in managing daily experimental schedules while adhering to weekly progress reporting.
Communication & Personality:
Fluent English: As all lab meetings are conducted entirely in English, you must possess strong English proficiency to discuss experimental designs and research outcomes effectively.
Outgoing Personality: We prefer students who are outgoing and eager to communicate. You will be expected to interact proactively with international peers and collaborate within our diverse research team.
Preferred Intern Educational Level
Preferred Education Level:
Open to all academic levels (Undergraduate, Master’s, and Ph.D. students).
Priority Consideration: Strong preference will be given to candidates who plan to pursue advanced degrees (Master’s/PhD) or seek long-term employment (including postdoctoral positions) in Taiwan after the internship.
Skill sets or Qualities
Skill Sets or Qualities Required
1. Technical Proficiency (Hard Skills)
Microbial Manipulation Experience (Required):
Candidates must have hands-on experience in general microbiology, including handling bacteria, fungi, or other microorganisms . Proficiency in aseptic techniques, microbial culturing, and basic molecular biology protocols is essential to successfully handle the experiments.
Note: Specific experience with slime molds is NOT required, but prior experience with fungi is a plus.
Experimental Design:
Ability to plan and execute experiments based on research objectives .
2. Work Style & Personality (Soft Skills)
American Management Style – Independence:
Our lab operates under an American management style . We are looking for self-disciplined students who can manage their own daily schedule and possess the ability to generate their own ideas for experimental design .Candidates must be capable of working independently while strictly adhering to weekly progress reporting schedules .
Outgoing & Collaborative:
We seek students with an outgoing personality who are eager to interact with others . You must be willing to collaborate actively with international lab members and Taiwanese students in a diverse environment .
Language Proficiency:
Fluent English is required. As all lab meetings are conducted in English , candidates must be able to present progress, discuss scientific concepts, and communicate daily in English without barriers.