Lab for Cell Dynamics
Research Field
I am a deeply curious person who has been fortunate enough to turn that curiosity into a career in science. With interdisciplinary training spanning biochemistry, cell biology, quantitative imaging, computation, and mathematical modeling, I lead the Lab for Cell Dynamics, where we investigate how cells process information, coordinate their behaviors, and collectively generate complex biological patterns during development. By uncovering the fundamental principles that govern cell and developmental dynamics, we hope to inspire new therapeutic strategies for cancer and age-related diseases.
My goal is not only to advance our understanding of cell dynamics, but also to cultivate a rigorous, collaborative, and nurturing research environment in which young scientists can explore bold questions, develop strong experimental and quantitative skills, and grow into independent thinkers. Through our internship program, I hope to share the excitement of scientific discovery and help students learn how to transform curiosity into testable questions, carefully designed experiments, and meaningful research.
Biological rhythms orchestrate functions in space and time for organisms to develop, to adapt, and to survive. My lab is interested in revealing hidden biological rhythms and in deciphering their underlying regulatory principles for biological control. Rhythmic systems that we investigate include oscillators, toggle switches and trigger waves, especially those that govern cellular survival, death, and differentiation. We take a multifaced quantitative approach integrating concepts and methods in biology, mathematics, engineering and informatics. I have an interdisciplinary background in quantitative biology, with trainings and expertise in microscopy, biochemistry, and mathematical modeling. Inspired by the intricate crosstalk between signaling and metabolism, my research group laid the groundwork of redox bistable switches that govern metabolic homeostasis and large-scale cell death propagation as trigger waves. One central question that we are currently addressing is: how the robustness and vulnerability of cellular redox state are governed by the redox regulatory network during physiological adaptation, stress response, and embryonic development. Our ultimate goal is to reveal general principles in biology for its rational design and control.
Philosophy: Our lab aims to provide a nurturing environment for junior scientists to thrive in a cross-disciplinary environment. We are generally attracted to fundamental, under-explored questions at the interfaces between disciplines, and prefer to do destructive science and sometimes night science.
Life is shaped by decisions. How cells choose to survive, die, or differentiate remains a fundamental question in biology. These decisions govern development, regeneration, and aging. We view cell fate as an emergent process driven by dynamic interactions among proteins and metabolites in space and time. Our research integrates cancer, stem cell, and developmental biology with mathematics, engineering, and computation to study how cellular decisions are made. By doing so, we aim to enable predictive understanding, rational design, and functional control of living systems for therapeutic applications in aging-related diseases, including cancer and neurodegeneration.
NSTC Outstanding Research Award (國家科學委員會傑出研究獎)
Academia Sinica Scholar Award (中研學者)
Academia Sinica Presidential Scholars Program
Academia Sinica Early-Career Investigator Research Achievement Award (中央研究院年輕學者研究成果獎)
23rd Y.Z. scientific/technological research paper award from Far Eastern Y.Z. Hsu Foundation (有庠科技論文獎)
Research Scholar Award, Foundation for The Advancement of Outstanding Scholarship (傑出人才基金會積極留任國內優秀學者獎) Mentoring College Student Research Creativity Award, Ministry of Science and Technology (科技部指導大專學生研究計畫創作獎)
Academia Sinica Career Development Award
Excellent Young Investigator Award (優秀年輕學者研究計畫), Ministry of Science and Technology, Taiwan
Talented Scholar Fellowship (科技部延攬特殊優秀人才補助), Ministry of Science and Technology, Taiwan
Academia Sinica Investigator Fellowship (中研院新聘學術獎), Taiwan
Ruth L. Kirschstein National Research Service Award - NIGMS (F32), U.S.
Genesis Award, Asia Pacific Developmental Biology Conference
Scholarship for Eukaryotic Gene Expression course, Cold Spring Harbor Laboratory
Scholarship for Embryology course, Marine Biological Laboratory
Graduate Travel Award, American Society for Biochemistry and Molecular Biology
Distinction M.Sc. honor degree, University of Sussex
Sheng-hong (Sheng) Chen was born and raised in Taipei, Taiwan. He was an undergraduate at National Taiwan University, where he majored in Zoology and worked with Alex Yu on the population genetics of Mus musculus. After graduation, he went to University of Sussex to do his M.Sc. in Artificial Life. For his thesis project, he worked with Inman Harvey to build an agent-based model to simulate the epidemic dynamics and evolution of the Foot-and-Mouth virus in a small-world network. He then did his Ph.D. at UC San Diego with Huilin Zhou, working on enzymology and quantitative proteomics of the DNA damage checkpoint. He received his Ph.D. in Biological Sciences in 2008 and moved to UC San Francisco and Harvard Medical School for postdoctoral training with Keith Yamamoto and Galit Lahav respectively. During this period, he worked on transcriptional dynamics of glucocorticoid receptor and p53 dynamics in single cells. He began his independent career in the Institute of Molecular Biology at Academia Sinica in 2016.