From 2023 to date, the applicant has implemented the Ministry of Health and Welfare's plans to assist in the establishment of the Chinese Pharmacopoeia Chromatographic Database.

Redox Biology 2022, 58, 102534 [SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson’s disease] (IF = 11.9, Ranking in Biochemistry & Molecular Biology: 15/319 = 4.7 %) → Epidemiological studies have linked herbicides and Parkinson’s disease (PD), with the strongest associations resulting from long exposure durations. Paraquat (PQ), an herbicide, induces PD-like syndromes and has widely been accepted as a PD mimetic. Currently, there is still no cure to prevent the progression of PD, and the search for effective therapeutic ways is urgent. Recently, the impairing activity of sirtuins (SIRTs), such as SIRT1, may correlate with PD etiology. However, the nonspecificity of SIRT1 agonists has made the protective mechanisms against PD unclear and hampered the therapeutic application of SIRT1. Thus, this study investigated the protective mechanism and therapeutic potential of SRT1720, a more specific agonist for SIRT1 synthesized by Sirtris, in alleviating the toxicity of PQ-induced cellular and animal models of PD. Here we show that SRT1720 alleviates PQ-induced toxicity in cell and animal models. Genetic silencing and pharmacological inhibition of SIRT1 attenuated SRT1720’s protection against PQ-induced toxicity. Moreover, SRT1720 not only attenuated PQ-induced increased oxidative stress and mitochondrial free radical formations but also decreased mitochondrial membrane potential. Furthermore, SRT1720 reversed PQ-induced decreased PGC-1α levels and mitochondrial biogenesis. Although PQ and SRT1720 elevated NRF2 and antioxidative enzyme levels, only PQ decreased antioxidative enzyme activity but not SRT1720. NRF2 and PGC-1α silencing attenuated SRT1720 protection against PQ-induced toxicity. SRT1720 targeted SIRT1 and activated downstream PGC-1α and NRF2 signalings to prevent PQ-induced toxicity involving oxidative stress and mitochondrial dysfunction. Thus, SRT1720 might have therapeutic potential in preventing PD.

Phytomedicine2024, 134, 155986 [Effects of the oxoaporphine alkaloid hernandonine on dengue virus. Evidence for its mechanisms of action] (IF = 8.3, Ranking in Integrative & Complementary Medicine: 1/45 = 2.2 %) → The results revealed notable antiviral properties of hernandonine, particularly in inhibiting dengue virus (DENV) during the early stages of infection. Mechanistic analysis demonstrated that, akin to genistein, wortmannin, methyl-β-cyclodextrin (MβCD), and lovastatin, hernandonine exerted an influence on cholesterol-rich lipid rafts. It also restrained the pseudopodial movement ability of cells, potentially through the downregulation of cytoskeleton and endocytosis regulatory genes or protein expression. Moreover, hernandonine’s virucidal activity was demonstrated. Hernandonine’s inhibition of DENV infection was further validated in a disease-relevant iPSC-derived cerebral organoids model, a novel DENV-2 infection system worthy of further application. 
Phytomedicine2019, 64, 152911 [Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR- dependent pathways in human endothelial progenitor cells] (IF = 8.3, Ranking in Integrative & Complementary Medicine: 1/45 = 2.2 %) → Garcimultiflorone K is a novel polyprenylated polycyclic acylphloroglucinol isolated from the stems of Garcinia multiflora that exhibits promising anti-angiogenic activity in human endothelial progenitor cells (EPCs). Purpose This study sought to determine the underlying anti-angiogenic mechanisms and pharmacological properties of garcimultiflorone K. Methods We examined the anti-angiogenic effects of garcimultiflorone K and its mechanisms of action using in vitro EPC models and in vivo zebrafish embryos. EPCs proliferation, migration, differentiation and capillary-like tube formation were effectively and concentration-dependently inhibited by garcimultiflorone K without any signs of cytotoxicity. Our investigations revealed that garcimultiflorone K suppressed EPCs angiogenesis through Akt, mTOR, p70S6K, and eNOS signaling cascades. Notably, garcimultiflorone K dose-dependently impeded angiogenesis in zebrafish embryos. Our data demonstrate the anti-angiogneic effects of garcimultiflorone K in both in vitro and in vivo models. Garcimultiflorone K appears to have potential in the treatment of angiogenesis-related diseases.

Bioorganic Chemistry 2025, 161, 108778 [Isolation, characterization, and biological evaluation of bioactive components from the stem bark of Broussonetia papyrifera: Antioxidant properties and apoptosis induction in breast cancer cells] (IF = 4.7, Ranking in Chemistry, Organic: 5/57 = 8.7 %) → Five previously undescribed compounds, including broussopapyrin A (1), broussopapyrin B (2), broussopapyrin C (3), broussocoumarin (4), and (S)-broussonone A (5), were isolated and structurally elucidated from the stem bark of Broussonetia papyrifera. These isolated new compounds, along with known compounds 6–15, were evaluated for their antioxidant and anticancer properties. Among the bioactive components, broussopapyrin A (1) exhibited potent DPPH (SC50 = 22.33 ± 1.50 μM) and ABTS (SC50 = 15.15 ± 2.07 μM) scavenging activities, significantly greater than the commercially available antioxidant, butylated hydroxytoluene (BHT) (DPPH SC50 = 139.41 ± 2.26 μM; ABTS SC50 = 92.15 ± 5.46 μM). Notably, broussopapyrin A (1) exhibited higher cytotoxicity against breast cancer cell lines, including MCF-7 (IC50 = 7.51 ± 1.21 μM) and MDA-MB-231 (IC50 = 19.73 ± 3.51 μM), compared to 5-FU (IC50 = 16.33 ± 2.44 μM and 68.19 ± 10.32 μM against MCF-7 and MDAMB-231, respectively), along with 2–2.5 folds greater safety at effective concentrations relative to doxorubicin. Furthermore, broussopapyrin A (1) demonstrated effectively apoptosis induction via regulating caspase-3, caspase-7, BAX, and Bcl-2 against breast cancer cell lines. These findings highlight bioactive components of B. papyrifera, especially for broussopapyrin A (1), as promising antioxidants and anticancer agents with both high efficacy and improved safety, paving the way for future development of therapeutic strategies targeting oxidative stress disorder and breast cancer.
 

Bioorganic Chemistry 2025, 161, 108516 [Anti-inflammatory activity of Pogostemon cablin: Bioactive components and their modulation of MAPK and NF-κB signaling pathway] (IF = 4.7, Ranking in Chemistry, Organic: 5/57 = 8.7 %) → In this study, 16 known compounds (1–15 and 17) and one semi-synthesized new compound, 5-hydroxy-3-isoprenyloxy-7,3′,4′-trimethoxyflavone (16), including flavonoids, pyranones, sesquiterpenes, and benzenoids, were obtained and characterized from aerial parts of P. cablin and investigated for their anti-inflammatory properties through the MAPK and NF-κB signaling pathways in LPS-induced RAW264.7 macrophages. Among the isolated compounds, rhamnazin (4), pachypodol (5), and (E)-2-methyl-6-(p-tolyl)hept-3-en-2-ol (15) exhibited potent anti-inflammatory activities in LPS-induced RAW264.7 macrophages. Rhamnazin (4) significantly modulated IκBα levels and reduced the expressions of phosphorylation of JNK and p38, indicating its effects on suppressing NF-κB activation and mitigating inflammation via MAPK signaling. Pachypodol (5) selectively inhibited iNOS and p-JNK expressions, showing specificity in its anti-inflammatory activity. (E)-2-Methyl-6-(p-tolyl)hept-3-en-2-ol (15) downregulated iNOS, p-Erk, and p-JNK expressions, demonstrating a broader inhibitory profile on pro-inflammatory mediators. Further molecular docking results demonstrated bioactive compounds 4, 5, and 15 possessed strong binding affinities with key residues, particularly Hem901, Pro344, and Glu371, consistent with their NO inhibition effects. In addition, in silico prediction of physicochemical properties confirmed favorable oral bioavailability and druglikeness, supporting their potential as lead compounds for anti-inflammatory drug development. These findings provide comprehensive molecular insight into the anti-inflammatory effects and reveal the therapeutic potential of P. cablin constituents as natural plant-derived NF-κB and MAPK-targeting anti-inflammatory agents, offering promising candidates for managing inflammatory diseases.

Chemico-Biological Interactions 2025, 407, 111357. [Myriscagayanone C, a new compound from the fruit of myristica cagayanensis, inhibits fMLP-induced respiratory bursts by specifically preventing Akt translocation in human neutrophils] (IF = 5.4, Ranking in Pharmacology & Pharmacy: 38/352 = 10.8 %) → Myriscagayanone C inhibits fMLP-induced neutrophil superoxide anion production by interrupting translocation of Akt to the plasma membrane, which affects the NADPH oxidase activity by preventing p47phox phosphorylation and translocation. Our research indicates that myriscagayanone C inhibits fMLP-induced Akt translocation, demonstrating its biological activity and underlying mechanism. This suggests that myriscagayanone C could be utilized as an anti-inflammatory agent. These findings provide valuable insights into the potential use of Myristica cagayanensis in traditional medicine. 
 

Antioxidants 2025, 14 (4), 413 [Pharmacological and molecular docking investigation of leaves of Eriobotrya japonica: antioxidant, enzyme inhibition, and anti-inflammatory effects]. (IF = 6.6, Ranking in Chemistry, Medicinal: 8/72 = 11.1 %) → The α-glucosidase inhibition results demonstrated that ethyl acetate and ethanol extracts exhibited the most potent inhibitory effects, with oleanolic acid (1), ursolic acid (2), and corosolic acid (3) showing IC50 values of 21.10 ± 1.48, 10.68 ± 0.76, and 13.83 ± 2.11 μM, respectively, significantly stronger than the acarbose (IC50 = 419.93 ± 29.15 μM). The AChE inhibition results revealed that n-hexane and ethyl acetate extracts possessed strong inhibitory effects, while triterpenoid compounds 1–4 showed AChE inhibition levels comparable to chlorogenic acid. Anti-inflammatory analysis results indicated ursolic acid (2) and rutin (6) possessed potent anti-inflammatory effects, with IC50 values of 20.18 ± 1.46 and 29.47 ± 1.19, respectively, against LPS-induced NO production of RAW264.7 cells. Further, Western blot analysis results indicated that ursolic acid (2) expressed significant inhibition against iNOS expression, demonstrating the anti-inflammatory mechanism. Overall, these findings highlight the biological potential of bioactive components and extracts from leaves of E. japonica as a natural source of supplements or candidates for antioxidant, anti-α-glucosidase, anti-AChE, and anti-inflammatory agents, offering promising applications in managing oxidative stress-related diseases, diabetes mellitus, Alzheimer’s disease, and inflammatory disorders.
 

Journal of Traditional and Complementary Medicine 2023, 13 (4), 379-388 [Hypericum sampsonii exhibits anti-inflammatory activity in a lipopolysaccharideinduced sepsis mouse model]. (IF = 3.0) → Hypericum sampsonii extract (HSE) suppressed NF-kB activation and proinflammatory molecules (TNF-α, IL-6, iNOS) in LPS-activated RAW 264.7 macrophages. Furthermore, oral administration of HSE (200 mg/kg) to LPStreated mice improved the survival rate, restored body temperature, decreased TNF-a and IL-6 in serum, and reduced IL-6 expression in bronchoalveolar lavage fluid (BALF). In lung tissues, HSE reduced LPS-induced leukocyte infiltration and the expression of proinflammatory molecules (TNF-α, IL-6, iNOS, CCL4 and CCL5). Three pure compounds isolated from HSE, including 2,4,6-trihydroxybenzophenone-4-O-geranyl ether, 1-hydroxy-7-methoxyxanthone and euxanthone, were demonstrated to exhibit anti-inflammatory activities in LPS-stimulated RAW 264.7 macrophages. The present study demonstrated the anti-inflammatory effects of H. sampsonii in vitro and in vivo.
 

Archiv der Pharmazie 2022, e2100448 [Synthesis of cinnamils and quinoxalines and their biological evaluation as anti-cancer agents]. (SCI, 2022 IF = 5.1) → We synthesized multiple cinnamils and quinoxalines to evaluate their anticancer activity. Cinnamils were used as precursors for quinoxalines via condensation with 1,2‐diaminobenzene. Among the 26 synthesized compounds reported in this article, we found that cinnamil 3l exhibited its inhibitory effect with an IC50 value of 1.45 ± 0.98 μM, significantly higher than doxorubicin (8.5 ± 0.85 μM) against pancreatic cancer cells (PANC‐1). Additionally, cinnamil 3l (IC50 10.98 ± 3.63 μM) showed less cytotoxicity than doxorubicin to Hs68 cells (0.92 ± 1.11 μM). The colony formation assay demonstrated that 3l obviously decreased the PANC‐1 cell viability, and Western blot assays confirmed that 3l markedly induced apoptosis of PANC‐1 cells through Bax, Bcl‐2, and caspase 3 signaling cascades. These results demonstrate that cinnamil 3l has great potential to be further developed as a promising chemotherapeutic agent for pancreatic cancer. 
 

Marine Drugs 2021, 19, 408 [Anti-cancer and anti-inflammatory activities of three new chromone derivatives from the marine-derived Penicillium citrinum]. (SCI, 2021 IF = 6.085) → Three new and uncommon chromone analogs, epiremisporine F (1), epiremisporine G (2), and epiremisporine H (3), were isolated from marine-origin Penicillium citrinum. Among the isolated compounds, compounds 2–3 remarkably suppressed fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 31.68 ± 2.53, and 33.52 ± 0.42 μM, respectively. Compound 3 exhibited cytotoxic activities against human colon carcinoma (HT-29) and non-small lung cancer cell (A549) with IC50 values of 21.17 ± 4.89 and 31.43 ± 3.01 μM, respectively, and Western blot assay confirmed that compound 3 obviously induced apoptosis of HT-29 cells, via Bcl-2, Bax, and caspase 3 signaling cascades.
 

Archiv der Pharmazie 2022, e2200486 [Synthesis of selenophene-based chalcone analogues and assessment of their biological activity as anti-cancer agents] (SCI, 2022 IF = 5.1) → Selenium is an essential micronutrient that is beneficial to human health. Selenium-containing drugs have been developed as antioxidants, anti‐inflammatory, and anticancer agents. However, the synthesis of selenium‐containing chalcones has not been fully explored. Therefore, we report the synthesis of novel selenophene‐based chalcone analogs and reveal their biological activities as anticancer agents. Among the seven synthesized molecules, compounds 6, 8, and 10 exhibited anticancer activity with IC50 values of 19.98 ± 3.38, 38.23 ± 3.30, and 46.95 ± 5.68 μM, respectively, against human colorectal adenocarcinoma (HT‐29) cells. Clonogenic assays and Western blot analysis tests further confirmed that compound 6 effectively induced apoptosis in HT‐29 cells through mitochondrial‐ and caspase‐3‐dependent pathways.
 

International Journal of Molecular Sciences 2021, 22, 7448 [Dibenzofuran, 4-chromanone, acetophenone, and dithiecine derivatives: cytotoxic constituents from Eupatorium fortunei] → Five new compounds, eupatodibenzofuran A, eupatodibenzofuran B, 6-acetyl-8-methoxy-2,2-dimethylchroman-4-one, eupatofortunone, and eupatodithie-cine, have been isolated from the aerial part of Eupatorium fortunei, together with 11 known compounds. Eupatodibenzofuran A and B featured a new carbon skeleton with an unprecedented 1-(9-(4-methylphenyl)-6-methyldibenzo[b,d]furan-2-yl)ethenone. Among the isolates, eupatodibenzofuran A exhibited potent inhibitory activity with IC50 values of 5.95 ± 0.89 and 5.55 ± 0.23 µM, respectively, against A549 and MCF-7 cells. The colony-formation assay demonstrated that eupatodibenzofuran A (5 µM) obviously decreased A549 and MCF-7 cell proliferation, and Western blot test confirmed that eupatodibenzofuran A markedly induced apoptosis of A549 and MCF-7 cells through mitochondrial- and caspase-3-dependent pathways.
 

Molecules 2020, 25 (24), 5911 [Secoiridoid glucosides and anti-inflammatory constituents from the stem bark of Fraxinus chinensis] → Qin Pi (Fraxinus chinensis Roxb.) is commercially used in healthcare products for the improvement of intestinal function and gouty arthritis in many countries. Three new secoiridoid glucosides, (8E)-4′′-O-methylligstroside (1), (8E)-4′′-O-methyldimethylligstroside (2), and 3′′,4′′-di-O-methyldemethyl-oleuropein (3), have been isolated from the stem bark of Fraxinus chinensis, together with 23 known compounds (4–26). The structures of the new compounds were established by spectroscopic analyses (1D, 2D NMR, IR, UV, and HRESIMS). Among the isolated compounds, (8E)-4′′-O-methylligstroside (1), (8E)-4′′-O-methyldemethyl- ligstroside (2), 3′′,4′′-di-O-methyldemethyloleuropein (3), oleuropein (6), aesculetin (9), isoscopoletin (11), aesculetin dimethyl ester (12), fraxetin (14), tyrosol (21), 4-hydroxyphenethyl acetate (22), and (+)-pinoresinol (24) exhibited inhibition (IC50 ≤ 7.65 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leuckyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, 9, 11, 14, 21, and 22 inhibited fMLP/CB-induced elastase release with IC50 ≤ 3.23 µg/mL. In addition, compounds 2, 9, 11, 14, and 21 showed potent inhibition with IC50 values ≤ 27.11 µM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation. The well-known proinflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6), were also inhibited by compounds 1, 9, and 14. Compounds 1, 9, and 14 displayed an anti-inflammatory effect against NO, TNF-α, and IL-6 through the inhibition of activation of MAPKs and IκBα in LPS-activated macrophages. In addition, compounds 1, 9, and 14 stimulated anti-inflammatory M2 phenotype by elevating the expression of arginase 1 and Krüppel-like factor 4 (KLF4). The above results suggested that compounds 1, 9, and 14 could be considered as potential compounds for further development of NO production-targeted anti-inflammatory agents.
 

Antioxidants 2024, 13 (8), 918 [Bioaffinity ultrafiltration combined with HPLC-ESI-qTOF-MS/MS for screening potential bioactive components from the stems of Dendrobium fimbriatum and in silico analysis] → Bioaffinity Ultrafiltration Combined with HPLC-ESI-qTOF-MS/MS for Screening Potential Bioactive Components from the Stems of Dendrobium fimbriatum and In Silico Analysis. This research suggests that the bio active extracts and components of D. fimbriatum stem could be studied further as hopeful candidates for the prevention or treatment of hyperglycemia, oxidative stress-related diseases, and nervous disorders.
 

Industrial Crops and Products 2026, 247, 123490 [Multi-functional Investigation of Bioactive Extracts and Constituents from the Root of Polygonum multiflorum] (SCI, 2024 IF = 6.2) → Eight solvent extracts and six bioactive constituents isolated from the roots of Polygonum multiflorum were systematically evaluated for antioxidant, anti-acetylcholinesterase, anti-α-glucosidase, and anti-inflammatory activities. Among the isolated compounds, tetrahydroxystilbene glucoside, resveratrol, emodin, rutin, and gallic acid exhibited significant biological activities. Molecular docking and in silico analyses further supported their interactions with α-glucosidase, acetylcholinesterase, and inflammatory targets. These findings demonstrate the potential of P. multiflorum as a source of multifunctional bioactive agents for the management of oxidative stress-related diseases, diabetes, neurodegenerative disorders, and inflammation.
 

Antioxidants 2026, 15, 688 [Bioactive Extracts and Constituents from Taraxacum mongolicum: Antioxidant, Anti-inflammatory, Enzyme-Inhibitory, and Molecular Docking Studies] (SCI, 2024 IF = 6.6) →  Bioactivity-guided fractionation of Taraxacum mongolicum led to the identification of several active constituents exhibiting antioxidant, anti-inflammatory, anti-acetylcholinesterase, anti-α-glucosidase, and anti-tyrosinase activities. Western blot analysis demonstrated suppression of inflammatory mediators, while molecular docking supported the interactions of active compounds with target proteins. These findings suggest that T. mongolicum possesses considerable potential as a source of functional food ingredients and lead compounds for drug development.
 

Industrial Crops and Products, 2026, 241, 122697  [Bioactive Extract and Component from Fruit Spikes of Prunella vulgaris L. Induce Apoptosis in Non-Small Cell Lung Cancer: An Integrative Network Pharmacology, Molecular Docking, and Experimental Validation Approach] (SCI, 2024 IF = 6.2)→  This study integrated network pharmacology, molecular docking, and experimental validation to investigate the anti-cancer effects of Prunella vulgaris against non-small cell lung cancer. Bioactive extracts and compounds significantly inhibited cancer cell proliferation and induced apoptosis through regulation of apoptosis-related proteins and signaling pathways. Network pharmacology analysis identified key therapeutic targets and pathways, while docking analysis supported the interactions between active compounds and target proteins. These findings provide scientific evidence supporting the development of P. vulgaris-derived agents for lung cancer therapy.
 

Industrial Crops and Products 2026, 241, 122698 [Bioactivity and in silico insights into 2-(2-phenylethyl)-4H-chromen-4-one and sesquiterpenoid constituents from agarwood (Aquilaria sinensis) as anti-inflammatory agents] (SCI, 2024 IF = 6.2) →  Three new compounds and thirteen known compounds were isolated and identified from the agarwood of Aquilaria sinensis. Among the isolated constituents, several chromone derivatives and sesquiterpenoids exhibited potent inhibitory effects on superoxide anion generation and elastase release in fMLP/CB-stimulated human neutrophils. Molecular docking analysis further suggested favorable interactions between the active compounds and the PI3Kγ binding site, providing mechanistic support for their anti-inflammatory activities. In addition, in silico physicochemical prediction indicated favorable drug-likeness-related properties for several bioactive compounds. These findings demonstrate that agarwood represents a valuable source of anti-inflammatory lead compounds and further support the potential application of its constituents in inflammation-related disorders.

Applied Research: Summarize valid patents, technology transfers, or research achievements mainly contributed by the applicant. Describe their impacts on society or economy.

[1] Valid patents: (1) New biphenyl compound extracted from Magnolia officinalis and bioactive components and preparation method. Invention patents: I515004. Republic of China (Taiwan). (2016.01.01~2031.08.24). (2) Flavonoids with anti-inflammatory activity, and the use of 5,3'-dihydroxy-7,4'-dimethoxyflavone. Invention patents: I533880. Republic of China (Taiwan). (2016.05.21~2034.08.21). (3) New secoiridoids and biologically active components extracted from Fraxinus chinensis and their preparation methods. Invention patents: I568443. Republic of China (Taiwan). (2017.02.01~2032.07.11). (4) Compounds and their pharmaceutical compositions, uses and extraction methods. Invention patents: I574966. Republic of China (Taiwan). (2017.03.21~ 2035.08.26). (5) Uses of Garcimultiflorone K. Invention patents: I593407. Republic of China (Taiwan). (2017.08.01~2035.06.30). (6) Compound and pharmaceutical composition, use and process extracting from Eriobotrya japonica leaf thereof. Invention patents: I640505. Republic of China (Taiwan). (2018.11.11~ 2036.12.19). (7) Compound and pharmaceutical composition, use and process extracting from Penicillium citrinum thereof. Invention patents: I764744. Republic of China (Taiwan). (2022.05.11~2041.06.01). (8) Compound and pharmaceutical composition, use and process extracting from Eupatorium fortunei thereof. Invention patents: I768946. Republic of China (Taiwan). (2022.06.21~2041.06.01). (9) Novel compound and pharmaceutical composition, use, method of extracting from Penicillium citrinum and synthesis method thereof. Invention patents: I773607. Republic of China (Taiwan). (2022.08.01~2041.12.06) (10) Hexadiene-3,4-dione or quinoxiline compounds or pharmaceutically acceptable salts thereof applied in preparation of pharmaceuticals as an inhibitory agent of pancreatic cancer. Invention patents: I776736. Republic of China (Taiwan). (2022.09.01~ 2041.11.14). (11) Chalcone compound containing selenium element, preparation method thereof, pharmaceutical composition containing same, and application of preparation of pharmaceutical composition for preventing or treating colorectal cancer. Invention patents: I811116. Republic of China (Taiwan). (2023.08.01~2042.09.22). (12) Uses of Polygonum sibiricum extract. Invention patents: I811116. Republic of China (Taiwan). (2024.02.11~2042.09.13).

[2] Technology transfers: (1) Technology transfer manufacturer: Natural Beauty Biotechnology Co., Ltd. Compound and pharmaceutical composition, use and process extracting from Eriobotrya japonica leaf thereof. Invention patents: I640505. Republic of China (Taiwan). (2018.11.11~2036.12.19). (2) Technology transfer manufacturer: Li-An Biochemical Technology Pharmaceutical Co., Ltd. New biphenyl compound extracted from Magnolia officinalis and bioactive components and preparation method. Invention patents: I515004. Republic of China (Taiwan). (2016.01.01~2031.08.24).

[3] Research achievements: 
Signed an Industry-University Cooperation Plan (No. 111A40001Y) with Sun Ten Pharmaceutical Co., Ltd. to assist in the research and development of anti-epidemic products such as "Ping An Fang Yu Yin", which can fight against "COVID-19", and won the "Nutritional and Health Food Innovation Award" issued by the "Taiwan Health Food Association" in 2023, and published paper in Processes 2022, 10, 2213. In addition, this R&D product also won the “2023 SNQ (Symbol of National Quality)” Award in Taiwan.
Processes 2022, 10, 2213 → COVID-19 is a global pandemic infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The herbal formula, Ping An Fang Yu Yin (PAFYY), has been used to prevent respiratory viral infections for many years. This study aims to evaluate the effect of PAFYY on SARS-CoV-2 infection, oxidative stress, and inflammation via in vitro, investigate the chemical composition by full constituent quantitative analysis, and verify its anti-viral potential against SARSCoV-2 using in silico. In this study, a total of eleven compounds, twenty amino acids, saccharide compositions, and trace elements were found and quantitatively determined by chromatographic techniques. PAFYY displayed free radical scavenging activity (DPPH, SC50: 1.24 ± 0.09 mg/mL), SOD activity (68.71 ± 1.28%), inhibition of lipoxygenase activity (75.96 ± 7.64 mg/mL) and interfered the interaction of SARS-CoV-2 spike protein and angiotensin-converting enzyme 2 (48.04 ± 3.18%). Furthermore, in-silico analysis results supported that liquiritin, 3,5-dicaffeoylquinic acid, and luteolin-7-O-glucoside with the highest affinity between SARS-CoV-2 RBD and human angiotensin-converting enzyme II (hACE2) receptor. Our findings suggest that PAFYY has the potential for anti-SARS-CoV-2 infection, anti-oxidation stress, and anti-inflammation, and may be used as supplements for amelioration or prevention of COVID-19 symptoms, as well as the representative compounds can be used for quality control of PAFYY in the future.s