National Kaohsiung University of Science and Technology

Enzyme and Engineering Lab

Chih-yu Cheng
https://www.scopus.com/authid/detail.uri?authorId=36056025600#

Research Field

Sustainable Development Research

Introduction

Dr. Chih-Yu Cheng is an Associate Professor and Chair of the Department of Marine Biotechnology at National Kaohsiung University of Science and Technology, Taiwan, with extensive experience in microbial enzyme engineering and bioprocess-oriented research.

Her research focuses on structure-guided engineering of chitosanases, integrating rational protein design with screening platforms to reprogram enzyme specificity and regulate chito-oligosaccharide product distributions. Her work emphasizes enzyme robustness, product controllability, and feasibility in reproducible production systems.

Through long-term studies on chitin- and chitosan-degrading enzymes, Dr. Cheng contributes to enzyme-enabled processing strategies relevant to microbial fermentation, biopolymer utilization, and applied bioprocess development.

The Enzyme and Engineering Lab (EELab) integrates enzyme science, microbial biotechnology, and bioprocess engineering to develop practical solutions for food innovation, sustainable biomaterials, and environmental applications. We provide an interdisciplinary and supportive research environment where students are encouraged to build strong experimental skills, independent thinking, and the ability to connect fundamental science with real-world challenges. We warmly welcome international interns who are interested in hands-on research and cross-disciplinary collaboration.


Research Topics
  • Protein engineering of chitosanase and chitinase
  • Chitooligosaccharide production and biocatalytic process development
  • Fungal pellet cultivation and mycelium-based future food research
  • Bioremediation of contaminated soil and residue valorization
  • Nanobiotechnology, biosensing, and applied microbial technology

Honor

Our laboratory has built a strong record of research publication, patent development, student mentorship, and innovation-oriented achievements. Recent honors and accomplishments include:

  • Best Paper Award at the 10th International Forum on Industrial Bioprocessing for research on the optimization of Ganoderma pellet production as a vegan food.
  • Multiple student innovation and entrepreneurship awards in 2021–2025 for projects related to mycelium cultivation, biodegradation, sustainable agriculture, and fungal biotechnology.
  • Poster Award for research on the improved bioremediation of PCDD/F-contaminated soil using fungal-derived systems.
  • Several invention patents in Taiwan and China covering recombinant chitosanase technology, chitooligosaccharide production, fungal pellet cultivation media, and bioremediation applications.
  • A strong publication record in international journals such as Foods, Process Biochemistry, Journal of Food Science and Technology, Environmental Pollution, Polymers, and Science of the Total Environment.

Educational Background

Dr. Chih-Yu Cheng holds a Ph.D. in Applied Chemistry from National Chiao Tung University, an M.S. in Chemical Engineering from Tatung University, and a B.S. in Bioengineering from Tatung University.


Job Description

The intern is expected to work in an interdisciplinary and international research environment. Depending on the assigned project, duties may include experimental design support, bioprocess optimization, analysis of enzyme or fungal cultivation performance, literature review, presentation of research progress, and assistance in preparing reports or academic outputs. This internship is designed to provide hands-on experience in sustainable biotechnology and strengthen the intern’s research skills, scientific communication, and problem-solving ability.

Preferred Intern Educational Level

Master’s student or senior undergraduate student in biotechnology, bioengineering, food science, microbiology, biochemical engineering, environmental science, or related fields

Skill sets or Qualities

  • Basic laboratory skills in biotechnology, microbiology, or biochemical experiments
  • Strong interest in sustainable biotechnology, enzyme applications, or fungal biotechnology
  • Ability to work independently and responsibly in a research environment
  • Good communication skills in English
  • Willingness to learn, collaborate, and participate in interdisciplinary research
  • Experience in microbial culture, biochemical analysis, or data processing is a plus