Dr. Jill Kao is an Assistant Professor in the Department of Biomedical Engineering and Radiological Sciences at National Yang Ming Chiao Tung University (NYCU). Her expertise in neuroscience was established during her graduate studies focusing on in vivo electrophysiology and further refined at the University of North Carolina at Chapel Hill (UNC-Chapel Hill), where she specialized in developing advanced small-animal MRI techniques. Dr. Kao occupies a unique niche in the field, bridging the gap between cutting-edge electrophysiology and innovative neuroimaging. Since returning to Taiwan, she has dedicated her career to translating high-level imaging technology into clinically significant research. By integrating her precise mastery of animal models with multi-parametric MRI and quantitative analysis, Dr. Kao provides the scientific evidence necessary to advance the precision diagnosis and treatment of complex neurological disorders.
Established in mid-2020 at NYCU, the Preclinical Brain Imaging (PBI) Lab focuses on probing functional and metabolic changes across the progression of neurological diseases. The lab utilizes state-of-the-art multimodal MRI techniques—including measurements of cerebral blood flow, white-matter integrity, blood-brain barrier disruption, and neural network connectivity—in both rat and mouse models. A hallmark of the PBI Lab is its deep integration with clinical medicine; through continuous dialogue with experts in neurology, neurosurgery, and pediatrics, the lab investigates highly relevant clinical issues such as mild traumatic brain injury (mTBI), stroke, and neonatal neurological disease. By linking sophisticated preclinical models with translational neuroimaging, the PBI Lab aims to uncover the pathological mechanisms of disease and pioneer innovations that move from the laboratory bench to the clinical bedside.
Our research is dedicated to the development of advanced small-animal Magnetic Resonance Imaging (MRI) technologies to bridge the gap between preclinical models and clinical practice. Through close collaboration with clinical experts, PBI Lab investigates the structural and functional evolution of the brain in neurological diseases. By linking multimodal MRI features with pathological mechanisms, our work provides a scientific foundation for the precision diagnosis and therapeutic strategies of neurological disorders.
PBI Lab has achieved several "world-first" milestones in neuroimaging and disease modeling.
We were the first to demonstrate the decisive impact of repetitive impact intervals on long-term prognosis and developed Diffusion Tensor Imaging (DTI) parameters that precisely correlate with neuroinflammatory progression. For the first time, we utilized mice with genetic variations in collateral circulation to study how vessel distribution affects stroke severity. We also pioneered the use of diffusion coefficients in brain cisterns to evaluate the impact of ischemic stroke on the cerebrospinal fluid (CSF) circulatory system. We published the first studies using MRI to detect Cortical Spreading Depolarization (CSD) in acute stroke and utilized ultrafast Doppler
imaging to characterize the behavior of cortical penetrating vessels during CSD events. We also published the first research using acute-phase MRI quantitative parameters to serve as predictive indicators for long-term neurodevelopmental outcomes in neonates. Recently, we also developed and optimized multiple high-resolution acquisition protocols for small-animal functional MRI (fMRI).
- 2024 Excellent Mentor Award, NYCU
- 2022 Outstanding Teaching Award, College Biomed. Engineering, NYCU
- 2016-2018 Outstanding Young Scholar Research Project, MOST, Taiwan
- 2015 Educational Stipend, International Society for Magnetic Resonance in Medicine
- 2014 Summa Cum Laude Merit Award, International Society for Magnetic Resonance in Medicine
- 2013 Best Basic Science Research Award, Biomedical Research Imaging Center Research Day
- 2013 Magna Cum Laude Merit Award, International Society for Magnetic Resonance in Medicine
- 2013 Educational Stipend, International Society for Magnetic Resonance in Medicine
- 2013 Young Investigator Travel Bursary, The International Society of Cerebral Blood Flow and Metabolism
- 2022- Higher Education Acadamey Fellowship
- 2020- Assistant Professor, Dept. BIRS, NYCU
- 2014-2019 Assistant Research Fellow, Neuroscience Research Center, Taipei Medical University
- 2012-2014 Postdoc Associate, University of North Carolina, Chapel Hill, NC
- Ph.D. from Institute of Biomedical Engineering, National Taiwan University, Taiwan
- B.S. from Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taiwan
Job Description
The PBI Lab at NYCU invites ambitious international students to apply for our Summer/Semester Internship. We are looking for highly motivated individuals who thrive in fast-paced, innovative environments and are eager to contribute to highly translational research. This internship offers a unique opportunity to work at the intersection of engineering and neuroscience.
Through our structured mentorship, you will develop a translational mindset while mastering:
- In vivo experimental techniques and ethical animal research
- Small animal MRI acquisition and multi-parametric imaging protocols
- Behavioral phenotyping for neurological disease models
- Advanced computational pipelines for neuroimaging and quantitative data science
Preferred Intern Educational Level
Students at all levels, from undergraduates to PhD, are welcome to apply.
Skill sets or Qualities
We embrace diversity in thought and training, and students from a wide range of academic backgrounds are highly encouraged to apply. While our core research intersects Neuroscience, Neurology, Biology, Biomedical Engineering, and Radiological Sciences, we welcome any curious mind eager to explore the brain.
Prospective interns should possess a strong desire to master specialized hands-on techniques in animal handling and advanced neuroimaging analysis, bridging the gap between biological models and high-tech diagnostics.