Chemical biology
Research Field
Associate Research Fellow (2018-)；Assistant Research Fellow (2011-2018)；B.S., National Chao Tung University (1991 - 1995)；Ph.D., Purdue University (1998 – 2004)；Postdoctoral Fellow, Albert Einstein College of Medicine (2004 - 2007)；Postdoctoral Fellow, University of North Carolina at Chapel Hill (2007 – 2010)；Senior Research Scientist, Scinopharm Taiwan (2010-2011) ；
The exciting field of chemical biology allows us to use chemistry to observe, investigate, and manipulate biochemical reactions within living organisms. Our team's focus is on developing innovative vesicle designs, such as liposomes and lipid nanoparticles (LNPs) that are surface decorated with various functional peptides and smart biomolecules. These vesicles can deliver drugs or macromolecules to living cells in response to cues externally (artificial signal) or internally from disease signals. We are also working on designing and synthesizing biosensors that can provide valuable insights into the workings of living cells. Our ultimate goal is to gain the ability to experimentally test and better understand biochemical reactions in living organisms, as well as repair living cells or tissues in vivo. Through our research, we aim to make significant contributions to the fields of chemical biology and biomedicine.
Our research team is pursuing several areas of chemical biology with a particular focus on developing innovative solutions for living cell and tissue repair. Our key areas of interest include:
- Utilizing liposomes and nanoparticles with surface-anchored smart molecules, such as peptides, for efficient delivery of macromolecules to living cells and tissues, which is critically important for tissue repair.
- Investigating cellular protein chemical modifications to create novel protein functions that are essential for living cell and tissue repair.
- Studying peptide-membrane interaction, which is fundamental to the development of smart lipid nanocarriers for targeted drug delivery.
- Developing fluorescence-reporting biosensors that provide valuable information about the chemical environment in living cells and tissues to better understand cellular processes and develop targeted therapies.
- Exploring the use of upconversion nanocrystals and nanoparticles for IR biomedical imaging and IR photo-releasing applications, which overcomes the limitation of visible light that has very poor tissue penetrating depth.
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Associate Research Fellow (2018-)；Assistant Research Fellow (2011-2018)；B.S., National Chao Tung University (1991 - 1995)；Ph.D., Purdue University (1998 – 2004)；Postdoctoral Fellow, Albert Einstein College of Medicine (2004 - 2007)；Postdoctoral Fellow, University of North Carolina at Chapel Hill (2007 – 2010)；Senior Research Scientist, Scinopharm Taiwan (2010-2011) ；