Tunghai University

Nutrition and Toxicology Laboratory

Ko-Hua Tso
https://animal.thu.edu.tw/en/faculty/faculty4/ju-tz-chuen/

Research Field

Basic Research Facilities

Introduction

Dr. Ko-Hua Tso is a specialist in animal nutrition and feed toxicology, with over a decade of experience in mycotoxin research and its application in the feed industry. During her doctoral studies, she was invited by the Taipei Feed and Animal Drugs Commercial Association to co-author the Mycotoxin Prevention and Control Manual, providing practical guidance for feed safety management and laying the foundation for academia–industry collaboration in Taiwan. She previously served as a senior research scientist and technical director at Dr. Bata Ltd., working at the company’s headquarters in Hungary and its branch in China. There, she led projects related to mycotoxin detoxifiers and feed additive testing. 

She is currently an assistant professor at the Department of Animal Science and Biotechnology at Tunghai University. Her research focuses on the toxic mechanisms of mycotoxins, detoxification strategies, poultry nutrition, and the risk assessment of heavy metals and environmental contaminants in feed. She is currently leading a project funded by Taiwan’s Ministry of Agriculture to integrate global mycotoxin regulations and risk management strategies systematically. In collaboration with the industry, she is also developing in vitro intestinal cell models to evaluate species-specific toxicological responses to mycotoxins in both livestock and companion animals, aiming to advance evidence-based applications of precision nutrition in mycotoxin management.

Dr. Tso has published multiple peer-reviewed articles in international SCI journals and has been invited to speak at academic and professional institutions, including Chiang Mai University in Thailand, National Chung Hsing University, and National Pingtung University of Science and Technology. She promotes sustainable feed safety and toxin prevention through integrated academic research and practical outreach.

The Precision Nutrition & Feed Toxicology Laboratory, led by Dr. Ko-Hua Tso, is dedicated to advancing feed safety, toxin risk assessment, and precision nutrition strategies for livestock and companion animals.

Our laboratory integrates animal nutrition, toxicology, cell biology, and regulatory science to address emerging challenges in global feed contamination, particularly mycotoxins, heavy metals, and environmental pollutants. We aim to translate mechanistic research into practical applications for industry and policy development, promoting sustainable and science-based feed management systems.

With over a decade of experience in mycotoxin research and feed industry application, Dr. Tso bridges academia, government, and international industry, fostering research that is both scientifically rigorous and practically impactful.


Research Topics

1. Mycotoxin Toxic Mechanisms and Species-Specific Responses

We investigate the cellular and molecular mechanisms of major mycotoxins, including:

  • Deoxynivalenol  
  • Aflatoxins
  • Zearalenone
  • Fumonisins
  • Ochratoxins
  • T-2 toxin

Using in vitro intestinal epithelial cell models for poultry, swine, and companion animals, we explore:

  • Barrier function disruption
  • Oxidative stress pathways
  • Inflammatory signaling
  • Apoptosis and cellular metabolism

Our goal is to clarify species-specific sensitivity differences and support precision nutrition-based mitigation strategies.

 

2. Detoxification Strategies and Functional Feed Additives

The laboratory evaluates physical, chemical, and biological detoxification approaches, including:

  • Mycotoxin binders
  • Enzymatic degradation systems
  • Phytogenic additives
  • Antioxidant supplementation

Through in vitro assays and feeding trials, we assess efficacy, safety, and interaction effects among multiple contaminants.

 

3. Risk Assessment of Heavy Metals and Environmental Contaminants

We conduct systematic analysis and risk evaluation of:

  • Antibiotic residue
  • Heavy metals and minerals

Our research supports regulatory updates and evidence-based safety standards for livestock and aquaculture feeds.

 

4. Global Mycotoxin Regulations and Policy Integration

Dr. Tso is currently leading a Ministry of Agriculture-funded project to systematically integrate global mycotoxin regulations, toxicity data, and prevention strategies.

This project aims to:

  • Update international regulatory limits
  • Compare risk management systems
  • Provide policy recommendations for Taiwan
  • Develop practical guidance for farmers and feed manufacturers

Honor

Invited Speaker, 
1. Animal and Aquatic Science Department of Chiang Mai University, Thailand, 2023
2. Animal Multi-Health Management and Care Course, National Chung Hsing University, Taiwan, 2022-2024
3. Veterinary Department National Pingtung University of Science and Technology, Taiwan, 2023
4. Taiwan Pet Nutrition and Health Food Association, Taiwan, 2025
5. The 5th Precision Nutrition Forum, Taiwan, 2025

Board Member, Taiwan Pet Nutrition and Health Association (2024–Present)


Educational Background
  1. Ph. D., Department of Animal Science, National Chung Hsing University
  2. Master, Department of Animal Science, National Chung Hsing University
  3. Bachelor in Department of Animal Science, National Chia-Yi University

Job Description

• Assist in studies on phytogenic feed additives as alternatives to antibiotics in poultry nutrition.

• Participate in animal husbandry and data analysis related to animal nutrition and feed toxicology.

Preferred Intern Educational Level

• Senior undergraduate student in Animal Science and Veterinary

• Graduate student (Master’s or PhD level)

Skill sets or Qualities

• Interest in animal nutrition, toxicology, or feed safety

• Basic laboratory skills (cell culture or animal husbandry experience is a plus)