Taipei Medical University

Wei-Lun Hung's lab

Wei-Lun Hung
https://wlhung.wixsite.com/website

Research Field

Agriculture

Introduction

Dr. Wei-Lun Hung received his Ph.D. in Food Science and Technology from National Taiwan University in 2012, after completing his B.S. in Nutrition and Food Science at Fu Jen University in 2005. He subsequently undertook postdoctoral training at National Taiwan University (2014–2015), Rutgers University (2015–2016), and the University of Florida (2016–2018), and joined Taipei Medical University in 2018. He is currently an Associate Professor in the School of Food Safety, College of Nutrition, at Taipei Medical University. Over the past decade, his research has focused on the chemistry, occurrence, and mitigation of process-induced toxicants, particularly reactive carbonyl species (α-dicarbonyls) and dietary advanced glycation end products (dAGEs), and on elucidating how dAGE exposure perturbs host metabolism, gut microbiota, and microbial metabolites in obesity-related models. Complementing this work, he has also investigated the health-promoting effects and molecular mechanisms of dietary phytochemicals against chronic diseases, spanning anti-obesity actions and inflammation-related pathologies, as well as organ-protective effects in vivo such as mitigating toxicant-induced liver injury. In parallel, his laboratory has developed robust analytical platforms to quantify process-induced harmful compounds and has identified practical intervention strategies using bioactive constituents from natural products to suppress their formation in real food systems. His current research focuses on integrating metabolomics with gut microbiome analyses to investigate how processing-induced harmful compounds contribute to chronic disease pathogenesis, particularly obesity and aging. His work has been published in leading peer-reviewed journals, including Food Chemistry, Food Chemistry X, Journal of Agricultural and Food Chemistry, Food & Function, Food Control, Molecular Nutrition & Food Research, and Journal of Functional Foods. He is a full member of Sigma Xi and has received Excellence in Review Awards from the Journal of Agricultural and Food Chemistry. He currently serves on the Editorial Advisory Board of the Journal of Agricultural and Food Chemistry, reflecting his continued commitment to advancing rigorous, mechanistic, and translational research at the interface of food chemistry, nutrition, and metabolic health.

Dr. Wei-Lun Hung's lab at Taipei Medical University focuses on understanding and mitigating processing-induced toxicants formed during thermal food processing, with particular emphasis on reactive carbonyl species (α-dicarbonyls) and dietary advanced glycation end products (dAGEs). By integrating food chemistry, advanced analytical chemistry (e.g., chromatography- mass spectrometry–based quantification), and translational nutrition research, the lab investigates how processing conditions and formulation factors drive toxicant formation in real foods and develops food-applicable intervention strategies using bioactive constituents from natural products. In parallel, the lab employs metabolomics, gut microbiome profiling, and animal models to elucidate how exposure to these compounds reshapes host metabolism and microbial metabolites, thereby contributing to chronic disease pathogenesis, particularly obesity and aging. Our long-term goal is to provide an end-to-end scientific framework that links chemical formation mechanisms to practical mitigation solutions and health-relevant mechanistic evidence, supporting safer food processing and improved public health.


Research Topics

Processing-induced food toxicants are pervasive in thermally processed foods and are increasingly implicated in oxidative stress, inflammation, and metabolic dysfunction. Building on validated analytical platforms and food-model-to-real-food translational studies, my research aims to (i) map how key processing/ingredient factors drive α-dicarbonyl and dAGE formation in common foods, (ii) develop practical mitigation strategies using bioactive constituents from natural products, and (iii) elucidate how exposure to specific AGE species and AGE-rich diets perturbs host metabolism, gut microbiota, and microbial metabolites in chronic disease contexts such as obesity and aging. In parallel, my program also investigates the health-promoting effects and mechanisms of dietary phytochemicals in chronic disease prevention.     

Research Topics:

1.Occurrence and analytical profiling of process-unduced toxicants in real foods

Develop and apply robust, validated quantitation workflows to profile process-induced toxicants across commercially processed foods, enabling exposure assessment and marker discovery for practical risk estimation.  

2. Key processing and formulation determinants of process-induced toxicant formation:

Define how ingredient composition and processing variables reshape α-dicarbonyl generation and downstream dAGE formation in staple products, and establish label-relevant predictors that can guide industry reformulation.  

3. Food-applicable intervention strategies using natural bioactive constituents:

Identify and mechanistically characterize natural-product constituents that suppress process-induced toxicant formation, and validate their efficacy directly in real food systems to support translational mitigation strategies.  

4. Metabolomics–microbiome mechanisms linking dAGE exposure to chronic disease:

Integrate metabolomics with gut microbiome analyses to delineate how specific AGE species and AGE-rich diets differentially remodel lipid metabolism, gut microbial ecology, and microbial metabolites in obesity-related models, with extension to aging-associated pathophysiology. 

5. Mechanistic studies of phytochemicals against chronic disease pathways:

Investigate how dietary phytochemicals modulate key biological processes involved in chronic diseases, including obesity-related adipose tissue remodeling and inflammation-driven pathologies through pathways, supporting their potential use in prevention strategies.


Honor

AWARDS, FELLOWSHIPS AND CERTIFICATIONS

  • Full Member, Sigma Xi, The Scientific Research Honor Society, 2024
  • Excellence in Review Award, Journal of Agricultural and Food Chemistry, 2022
  • Outstanding Performance as Top 10 Most Cited Articles of the Journal of Food and Drug Analysis, 2020
  • Excellence in Review Award, Journal of Agricultural and Food Chemistry, 2017
  • Fellowship of Postdoctoral Research Abroad Program, Ministry of Science and Technology, Taiwan, 2015
  • Award of Academic Research Thesis in Doctor, College of Bioresources and Agriculture, National Taiwan University, Taiwan, 2011
  • Food Technologists, National Certification, issued by Ministry of Examination, Taiwan, 2011

Educational Background
SchoolCountryDepartment/DivisionDegree/trainingDate
National Taiwan UniversityTaiwanFood Science and TechnologyPh.D.Sep. 2006–Jun. 2012
Fu Jen UniversityTaiwanNutrition and Food ScienceB.S.Sep. 2001–Jun. 2005 
National Taiwan UniversityTaiwanGraduate Institute of Food Science and TechnologyPostdoctoral Research AssociateFeb. 2014 – Jul. 2015
Rutgers UniversityU.S.A.Department of Food SciencePostdoctoral Research AssociateAug. 2015 – Feb. 2016
University of FloridaU.S.A.Department of Food Science and Human NutritionPostdoctoral Research AssociateMar. 2016 – Jul. 2018