High throughput biosensing lab
Research Field
Research Interests: Protein microarray, Host and microbial interactions, High throughput technology, Exercise physiology, Virology, and Bioinformatics
Our laboratory mainly uses high-throughput methods to discuss the direction of vaccine protection against diseases, the cause of infection, drug screening, etc., and uses viral envelope to purify membrane proteins to explore major pathogenic biomarkers.
G protein-coupled receptors (GPCR) are the most important family for signal transduction and drug development. However, the seven transmembrane domains increase the difficulty to purify and study GPCRs. Here, we developed virion-display (VirD) technology to express functional GPCR on the virus envelope and applied it to all non-olfactory GPCRs. We used VirD technology to detect the specificity of biologicals, measure the binding affinity of small molecules, and identify receptors that are important in bacterial invasion. Due to the pandemic of SARS-CoV-2, our group developed a human coronavirus (HCoV) protein microarray and SARS-CoV-2 variant (CoVariant) protein microarray for specificity analysis. They can be applied to immunosurveillance, disease detection, vaccine assessment, and drug specificity tests. We published our results in the Journal of the American Chemical Society, Nature Communications, Biosensors and Bioelectronics, Analytical Chemistry, and Molecular & Cellular Proteomics. Collaborations and students are most welcome!
SARS-CoV-2
Due to the recent raging novel coronavirus, a human coronavirus protein chip has been developed for detecting blood antibody response, which has high detection sensitivity, high clinical sensitivity, and high clinical specificity, and is used in monitoring immune response, finding infection, vaccine response, drug development, etc. Now that mutant strains are spreading worldwide, it is unclear whether vaccines can protect against multiple strains. The team developed the world's only high-throughput Coronavirus variant (CoVariant) protein array to evaluate the response after vaccination.
G protein-coupled receptors (GPCRs)
It is a very important membrane protein in information transmission and drug development. Due to the difficulty in protein expression and functional research due to the structure of seven transmembrane structures, developed a virus expression method-embedding GPCRs in the viral envelope, in addition to maintaining the configuration And functions, simpler purification and production of protein chips, GPCR chips can be used to detect the specificity of antibody drugs, ligand specificity, search for infection receptors and drug development, etc.
Outstanding Industry–Academia Collaboration Achievement Award, Excellent Award, 2026
Fulbright Research Abroad Fellowship, Fulbright Foundation, 2026
International Distinguished Inventor, Academic Kuo-Kuang Medal, 2025
Clinical Innovation Award, 21st National Innovation Award, 2024
Excellence Award, Industry–Academia Collaboration Program, Department of Engineering and Technologies, National Science and Technology Council (NSTC), 2024
Excellence Award, 21st National Innovation Award, 2024
Selected Cover Article, Analytical Chemistry, 2024
Outstanding Academic Research Award, 2024
Excellence Award, 20th National Innovation Award, 2023
Future Tech Award, National Science and Technology Council (NSTC), 2023
Outstanding Academic Research Award, 2023
Clinical Innovation Award, 19th National Innovation Award, 2022
Exhibitor, Future Tech Award, 2022
Outstanding Academic Research Award, 2022
Academic Research Innovation Award, 18th National Innovation Award, 2021
Outstanding Award, Young Scholar Innovative Research and Development Achievement Selection, Taiwan Comprehensive University System, 2021
2030 Young Scholar Research Program, Ministry of Science and Technology (MOST), 2021–2025
Distinguished Award, Preliminary Research Program for Industry–Academia Collaborative Innovation and Entrepreneurship, 2021
Honorable Mention, Young Scholar Innovative Research and Development Achievement Selection, Taiwan Comprehensive University System, 2020
Postdoctoral Research Abroad Fellowship, Ministry of Science and Technology (MOST), 2016–2017
Excellent Paper Award, Kyoto, Japan, 2009
Outstanding Teaching Assistant Award, 2009
| National Cheng Kung University, Taiwan | B.S. | 2005 | Environmental Engineering, Minor in Life Science |
| National Cheng Kung University, Taiwan | Ph.D | 2012 | Graduate Institute of Basic Medical Science |
| 2024~present | Division Director, Research & International Collaboration Division, Core Facility Center, National Cheng Kung University, Taiwan |
| 2025~present | Director, Taiwan Kawasaki Disease Care Association |
| 2023~present | Associate professor, Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Taiwan |
| 2023~2024 | Consultant, GeoNet Co., Ltd., Taiwan |
| 2019~2023 | Assistant professor, Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Taiwan |
| 2015~2019 | Postdoc, Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, USA |
| 2013~2015 | Postdoc, Graduate Institute of Systems Biology and Bioinformatics, National Central University, Taiwan |
| 2012~2013 | Postdoc, Department of Physiology, National Cheng Kung University, Taiwan |