I am an assistant professor at the National Yang Ming Chiao Tung University (NYCU) in the Institute of Food Safety and Health Risk Assessment. My academic foundation was built at National Taiwan University and National Tsing Hua University, where I earned my Ph.D. in physical chemistry through the TIGP program at Academia Sinica. Before joining NYCU, I spent four years conducting advanced postdoctoral research at two of the world’s most prestigious institutions: Stanford University under Prof. Richard N. Zare and ETH Zürich under Prof. Renato Zenobi. My professional journey also includes serving as an associate professor at National United University (Chem E.) and as a quality manager for a TAF-accredited pesticide detection center. My expertise lies at the intersection of analytical chemistry and advanced mass spectrometry (MS), with a specialized focus on instrumentation and methodology development. I possess an extensive technical skill set, including the development of ambient soft-ionization sources, ultrahigh spatial-resolution TOF imaging MS, and high-throughput sampling via functionalized paper-based analytics. A significant portion of my research has focused on microdroplet chemistry, in which I investigated how droplets can accelerate chemical reactions relative to bulk phases. Having collaborated extensively with world-class scholars across the U.S., Switzerland, and Taiwan, I am deeply committed to providing high-quality, international-standard mentorship to students from diverse backgrounds.

Our laboratory bridges physical chemistry and analytical innovation to address challenges in food safety, environmental forensics, and clinical diagnostics. We offer a structured research environment that transitions from fundamental discovery to deployable technology:

Foundations (Fundamental Innovation & Instrumentation):

• Instrumentation Engineering: We developed time-of-flight mass spectrometers with optimized ion optics for ultrahigh mass resolving power and submicron spatial resolution imaging.
• Microdroplet Chemistry: We pioneered the study of droplet-accelerated reactions, demonstrating their potential for green synthesis and alternative fuel development.
• Aptapaper Technology: Funded by Merck KGaA, we developed an aptapaper—an aptamer-functionalized glass fiber platform used for the rapid upconcentration and high-throughput screening of trace toxins in food.
• Advanced Dissociation Methods: We established ambient infrared-assisted dissociation to achieve the precise structural identification of complex carbohydrate isomers.
• Ambient Ionization Sources: We engineered soft ionization sources such as dielectric barrier discharge ionization.
   

Current Focus (Field Applications & Advanced Speciation):

• Precision Metal Speciation: We are perfecting breakthrough curve-assisted ICP-MS methods to achieve quantitative native speciation of trace metal ions in semiconductor-grade chemicals.
• Emerging Contaminant Mapping: Our future projects aim to integrate plasma-based MS with novel separation techniques to track the distribution of PFAS and other persistent organic pollutants in complex environmental matrices.
• Precision Health & Bioactives: We are deepening our research into natural product bioactives, correlating the phenolic profiles of mushrooms with their antioxidant and anti-cancer capabilities to support precision health development.