Kaohsiung Medical University

Materia Medica

Chien-Ju Lin
https://wac.kmu.edu.tw/qur/profiles.php?id=1065021

Research Field

Medicine

Introduction

I am an Assistant Professor at the School of Pharmacy, College of Pharmacy, Kaohsiung Medical University. I received my Ph.D. degree in Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University and has extensive postdoctoral and academic experience in pharmacology, molecular biology, and translational biomedical research.

My laboratory focuses on natural product pharmacology and mechanistic studies of disease-related cellular processes. My research aims to identify and characterize bioactive compounds and crude extracts derived from natural substances, Traditional Chinese Medicine, and synthetic small molecules with therapeutic potential against cancer and viral infections.

A central theme of the laboratory is understanding the molecular mechanisms underlying therapeutic efficacy, with a particular emphasis on the regulation and crosstalk among different cell death pathways. By integrating approaches from molecular biology, oncology, and cell death models, my research seeks to bridge traditional medicine and modern biomedical science, contributing to the development of innovative therapeutic strategies and fostering international research collaborations.

Our laboratory welcomes undergraduate research students and graduate students from Taiwan and abroad who are interested in natural product and small molecules research. The primary focus of the lab is the discovery of bioactive compounds from Traditional Chinese Medicine and other natural sources with anticancer or antiviral activities, followed by systematic investigation of their underlying molecular mechanisms.

Training in the laboratory integrates structured instruction with hands-on experimental practice, enabling students to build a solid foundation in oncology, pharmacology, molecular biology, and cell death pathways, as well as to develop strong technical skills. Students are trained across the full research workflow, including experimental design, laboratory execution, data analysis, figure preparation, and scientific interpretation, with the goal of fostering independent research ability and critical thinking.

The laboratory’s previous research achievements include mechanistic studies on the anticancer effects of natural compounds such as resveratrol, honokiol, methanolic extracts of Cimicifuga foetida, and methanol and water extracts of Artemisia argyi. In addition, the lab investigates the antiviral mechanisms of hydrolyzable tannins purified from Terminalia chebula Retz. Through this research environment, IIPP students will gain comprehensive research training and meaningful experience in translational natural product research.


Research Topics

The research in our laboratory focuses on the discovery and mechanistic characterization of bioactive compounds derived from Traditional Chinese Medicine and other natural products with anticancer and antiviral activities. We aim to identify active components from herbal extracts and natural substances and to elucidate their molecular mechanisms of action, particularly in relation to cancer biology and virus infections. Our studies integrate pharmacology, molecular biology, oncology, and cell death models to understand how these compounds regulate cellular signaling pathways and different forms of cell death. Through this research theme, IIPP students will gain exposure to interdisciplinary biomedical research that bridges traditional medicine and modern molecular science.


Honor

Outstanding Faculty Advisors for Academic Year 2020, 2021, 2022, 2023, 2024


Educational Background

2005-2012

 Ph. D., Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University

2004-2005

M. S., Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University

1999-2003

B. S., School of Pharmacy, College of Pharmacy, Taipei Medical University


Job Description

We may make some formulations of the effective compounds against cancer.

Preferred Intern Educational Level

undergraduate student, or master's student

Skill sets or Qualities

Cell culture
Western blot