With the time as an Associate Professor at National Chung Cheng University and prior academic roles, I specialize in computational biophysics, molecular dynamics simulation, and protein structure prediction. My work leverages physicochemical principles to explore molecular-level biological processes and their implications for neurodegenerative diseases and protein-DNA interactions.
At CCU, I focus on using advanced computational techniques to analyze protein-protein and protein-DNA interactions, combining atomistic and coarse-grained molecular simulations. My aim is to contribute to solving critical biochemical challenges by elucidating the structural and dynamic relationships in functional biomolecular systems.
Research in MYTLab is primarily at the interface of physics, chemistry, and biology. We employ physical and chemical theories to understand biological processes from a molecular perspective. Our research focuses on computational studies on protein-protein/protein-nucleic acids interactions using multi-scale molecular dynamics (MD) simulations (e.g., all-atom and coarse-graining approach). We aim to understand how biological specificity influences a cell’s function at the molecular level. Find out how you can contribute.
Protein Aggregation & Amyloid Dynamics
– Developed a mechanistic framework integrating coarse-grained molecular simulations and stochastic modeling to dissect amyloid aggregation. Identified how monomer diffusion (Aβ42), peptide morphology (proline-substituted oligomers), and surface-guided nucleation collectively regulate the kinetics of fibril growth. Advanced theoretical tools by introducing the method of second stochasticization to model aggregation as ensembles of reactive trajectories. (Protein Sci. 2025; JPCB 2021/2023; Front Mol. Biosci. 2021)
– Integrated nucleation theory with coarse-grained MD to explain amyloid formation and energy landscapes of Aβ. (PNAS 2016, JACS 2017; ∼270 citations)
Protein–DNA and Cytoskeletal Regulation
– Elucidated post-translationally driven oligomerization of cofilin via disulfide bond forma tion, revealing key dimer–tetramer intermediates and their impact on actin filament binding in cytoskeletal remodeling. (JPCB 2024)
– Revealed how charge-driven DNA bending and multimeric Fis–DNA architectures jointly shape transcription factor binding specificity and intersegment transfer dynamics. (JACS 2022, JACS 2025)
– Developed kinetic models of Fis–DNA binding via multiscale simulations, challenging ther modynamic assumptions of gene regulation. (JACS 2016, JACS 2019, Protein Sci 2016; ∼165 citations)
• Large-scale Research Award, EMSL, Pacific Northwest National Laboratory, USA (2025)
• 2030 Cross-Generation Young Scholars Program, NSTC, Taiwan (2024–2027)
• Young Scholar Award, National Chung Cheng University (2025)
• Outstanding Research Award, National Chung Cheng University (2024)
• Research and Teaching Awards, Tamkang University (2019–2021)
• Dissertation Award–Excellence in Physical Chemistry, Chinese Chemical Society (2011)
—Associate Professor, National Chung Cheng University, Taiwan (2025.8–Present)
Department of Chemistry and Biochemistry
Core Member, NCTS– Nanoscale Physics & Chemistry Division
—Assistant Professor, National Chung Cheng University, Taiwan
Department of Chemistry and Biochemistry (2023.2–2025.7)
Core Member, NCTS– Nanoscale Physics & Chemistry Division
—Assistant Professor, Tamkang University, Taiwan (2018.8–2023.1)
—Postdoctoral Research Associate, Rice University, USA (2014.10–2018.7)
Center for Theoretical Biological Physics
Advisor: Prof. Peter G. Wolynes; Co-Advisor: Prof. Margaret S. Cheung (PNNL)
—Ph.D., Physical Chemistry, National Taiwan University, Taiwan (2011) Thesis: Theoretical Studies of Protein Folding Advisor: Prof. Sheng-Hsien Lin
—B.Sc., Chemistry, National Taiwan Normal University, Taiwan (2005) Research Mentor: Prof. Ying-Chieh Sun