National Taiwan Normal University

Organic Biochemistry Laboratory

Ling-Hsien Tu
https://scholar.lib.ntnu.edu.tw/zh/persons/ling-hsien-tu/publications/

Research Field

Chemistry

Introduction

Dr. Ling-Hsien Tu is currently a Professor in the Department of Chemistry at National Taiwan Normal University, a position she has held since August 2024. Dr. Tu’s academic journey began with her Ph.D. in Chemistry, which she earned from Stony Brook University, New York, in August 2014. Her doctoral research focused on "Formation and Inhibition of Islet Amyloid in Type 2 Diabetes", under the guidance of Dr. Daniel P. Raleigh. Before joining National Taiwan Normal University, Dr. Tu gained valuable postdoctoral experience at the Genomics Research Center, Academia Sinica. She was a Distinguished Postdoctoral Scholar starting in January 2015. Dr. Tu’s research interests primarily revolve around amyloid formation, a complex process involving the polymerization of monomeric peptides or proteins into unbranched fibrils. Her work extends beyond understanding the underlying mechanisms of amyloid formation to developing therapeutic strategies. These strategies include the use of natural compounds, polymers, and nanomaterials to prevent amyloid formation. Additionally, her research group is actively engaged in identifying fluorescent molecules that can effectively distinguish different aggregated states.

My research interests mainly focus on amyloid formation, an unusual process in which hundreds to thousands of monomeric peptides or proteins polymerize into long, starch-like but unbranched fibrils. In addition to understanding the mechanism of amyloid formation, we have also developed therapeutic strategies, including the use of natural compounds, polymers, and nanomaterials, to prevent amyloid formation. On the other hand, we were developing methods that could be utilized to detect amyloids. 
 


Research Topics

Engineering Amyloidogenic Peptides as Functional Antimicrobials

The global escalation of antibiotic resistance necessitates the development of alternative therapies, such as antimicrobial peptides (AMPs), which offer broad-spectrum activity and a lower risk of resistance development. Despite their potential, clinical translation remains limited by short half-lives and restricted administration routes. As chemists, we address these challenges by developing innovative molecular strategies that focus on islet amyloid polypeptide (IAPP), an amyloidogenic protein with demonstrated microbicidal properties. Specifically, we address the misfolding of IAPP; while historically associated with proteopathies, we seek to harness this process for beneficial "microbe agglutination", a key innate immune function that entraps and clears pathogens. Our innovative approach treats IAPP misfolding not as a byproduct, but as a functional conformational switch to provide a high-resolution thermodynamic and structural understanding of how peptide assembly can be directed for therapeutic benefit.


Honor

Distinguished Postdoctoral Scholar, Genomics Research Center, Academia Sinica, Jan 2015-Jul 2016

Lee Myers Award for Outstanding Doctoral Chemistry Student, 2014


Educational Background

Aug. 2008- Aug 2014  Ph. D., Chemistry, Stony Brook University, Stony Brook, New York

Sep. 2003- Jul. 2005   M.S., Chemistry, National Taiwan Normal University, Taipei, Taiwan


Job Description

Interns will receive hands-on training and contribute to projects involving:

Advanced Synthesis: Solid-Phase Peptide Synthesis (SPPS) and microwave-assisted techniques.

Molecular Modification: Site-specific labeling and chemical cyclization.

Precision Purification: High-Performance Liquid Chromatography (HPLC) and characterization via LC-MS.

Interdisciplinary Application: Exploring the synergy between peptide chemistry and functional materials.

Preferred Intern Educational Level

Senior Undergraduate or Master’s students in Chemistry, Materials Science, Chemical Engineering, or related fields.

Skill sets or Qualities

Core Interests: A strong passion for peptide chemistry, nanomaterials, and functional molecular design.

Mindset: A proactive learner who is comfortable working both independently and as part of a collaborative research team.

Future Goals: We particularly encourage applications from students considering pursuing PhD studies in Taiwan in the near future.