I am a Principal Investigator at the Institute of Biomedical Sciences, Academia Sinica, working on MRI/NMR method development rooted in physical chemistry and molecular imaging.

My research philosophy emphasizes that MRI contrast should be mechanistically interpretable rather than purely empirical. I focus on building imaging methods that explicitly connect nuclear spin physics, molecular exchange, diffusion, and energy transfer to quantitative imaging signals, and on validating these connections through experiments rather than post hoc fitting.

My work spans multiple MRI modalities, including CEST/DGE, hyperpolarization, diffusion, susceptibility-related modeling, and contrast agent development. Across these areas, I prioritize clear physical assumptions, quantitative rigor, and experimental testability, with the long-term aim of advancing MRI as a tool for probing molecular and microstructural processes in vivo.

The laboratory focuses on MRI/NMR-based methodology development at the interface of physical chemistry, molecular imaging, and neurovascular biology. Rather than applying existing imaging tools as black boxes, we aim to understand and redesign MRI techniques from first principles.

Our work combines theoretical modeling, pulse sequence design, custom RF hardware, and in vivo experiments, supported by quantitative data analysis and AI-assisted pipelines. The lab environment encourages interns and researchers to engage with both conceptual foundations and practical implementation, gaining experience in how imaging methods are constructed, validated, and translated to biological questions.

Projects in the lab typically involve close interaction between model development and experimental testing, with a strong emphasis on learning how assumptions propagate into measurable imaging outcomes.