Biomedical Photonics Laboratory
Research Field
collaborations
| Year | Title |
|---|---|
| 110 | 高分子基材製程開發與生醫應用 |
Government projects/Ming Chi University of Technology projects
| Year | Name of Project |
|---|---|
| 107 | 結合人工智慧與節約能源的新型導電散熱裝置 |
論文 SCI/SSCI/AHCI/TSSCI Research Papers
| 年 | 題目 | 刊物名稱 | 卷 | 起始頁 |
|---|---|---|---|---|
| 2020 | Heat dissipation and electrical conduction of an LED by using a microfluidic channel with a graphene solution | APPLIED THERMAL ENGINEERING | 175 | 115383-1 |
| 2019 | Enhancement of microcantilever beams fabrication and determination of their mechanical properties using nanoindentation | MICRO & NANO LETTERS | 14 | 788 |
| 2018 | Design and application of an LED using a liquid conductor for dissipating heat and conducting electricity | MICRO & NANO LETTERS | 13 | 768 |
| 2016 | Particles Sorting in Micro Channel Using Designed Micro Electromagnets of Magnetic Field Gradient | Journal of Magnetism and MagneticMaterials | 407 | 209 |
| 2016 | Extension and denature temperature of dsDNA molecules at various magnetic forces by using magnetic tweezers | Micro & Nano Letters | 11 | 196 |
Experience
- Precision Machinery Promotion Group, Ministry of Economic Affairs, 1 year;
- Electronics Industry Research Institute, Industrial Technology Research Institute, 5 years;
- Mechanical Engineering Department, Ming Chi University of Science and Technology, 16 years.
- Project leader of the fully functional disease detection laboratory chip project ( ITRI )
- Project leader of hot bubble film driven drug delivery system ( ITRI )
- Adjunct Assistant Professor, Institute of Bio-Industry and Mechanical Engineering, National Taiwan University
- Adjunct Assistant Professor, Institute of Biotechnology, National Chiao Tung University
- Adjunct Assistant Professor, Institute of Mechatronics, Taipei University of Technology
His lab developing various biomedical applications such as electroporation chip, BioMEMS, Nanotechnology, Micro-fluidic Systems, Biomedical Optoelectronics, Magneto-optical Technology.
We propose cells can be descended using magnetic attraction, which leads to shorter experimental time and higher efficiency. We used an electroporation chip with adjustable electromagnetic field as the experimental platform, and tested Escherichia coli and 6-nm magnetic beads combined with DNA plasmid. The magnetic beads were positively charged and easy to bind to the negatively charged cell membrane of E. coli. The magnetic beads and E. coli could be attracted quickly to the bottom because of the electromagnet and could reduce operational time and enhance transfection efficiency. The descent velocity of E. coli under magnetic attraction was considerably higher than that of E. coli without magnetic attraction. After electroporating and culturing, we obtained the results for E. coli with drug resistance and calculated the number of colony as the transfection efficiency. The achieved transfection efficiency using magnetic beads was seven-fold higher than that without magnetic bead. The following optimum parameter values were determined: 1.4 × 1014 bead/ml for nano-magnetic bead concentration, 200 Gauss for magnetic flux density, and 40 s for magnetic attraction lasting time. The results will help develop transfection applications for low-descent-velocity cells. Using liquid conductors instead of metal solid conductors, using chips to detect blood sugar in tears and integrating them into contact lenses.
- biomedical applications
- Electroporation chip and BioMEMS, Nanotechnology
- Micro-fluidic Systems, and Biomedical Optoelectronics
- Magneto-optical Technology
- Microfluidic and gene transfection
- Magnetic tweezers and heat transfer
- Won the Outstanding Contribution Review Award from the international journal Lab on a Chip.
- (Certificate of Outstanding Contribution in Reviewing from Materials Science & Engineering B )
- The Executive Yuan Ministry of Science and Technology's First Innovation and Entrepreneurship Competition - “Outstanding Entrepreneurship Award” in 2012.
- 3nd place in the 2005 National Taiwan University Department of Geological Sciences Youth Forum Competition.
- Xinchang Electronics-Ming Chi University of Science and Technology Department of Mechanical Engineering Industry-Academic Cooperation Project-Co-Project Host.
He has received his PhD in Institute of Aeronautics and Astronautics, National Cheng Kung University (1991-1995), Taiwan.
Job Description
ELectrochemical biosensors based on nanomaterials development
Preferred Intern Education Level
Master and PhD
Skill sets or Qualities
Nanomaterials, Biosensors, Materials Chemistry