National Taiwan University

Synthetic Biology and Biofabrication

Hsuan-Chen Wu
https://bst.ntu.edu.tw/BST2023EN/News_Content_n_168171_s_212236.html#gsc.tab=0

Research Field

Emerging/Other Fields

Introduction

Dr. Hsuan-Chen Wu is an Associate Professor in the Department of Biochemical Science and Technology at National Taiwan University. Dr. Wu received his Ph.D. in Bioengineering from the University of Maryland, where he specialized in synthetic biology and biomolecular engineering. His research interests encompass synthetic biology, metabolic engineering, biofabrication, and biomaterials, with a focus on cellular reprogramming, quorum sensing, biotherapeutics production, and the development of functional biomaterials. Dr. Wu has extensive experience mentoring students and leading interdisciplinary research projects, and his work has been published in leading scientific journals. 

The Wu Lab at National Taiwan University focuses on advancing synthetic biology and biofabrication for novel biomaterials and biomedical applications. The team employs cutting-edge techniques to design and produce next-generation materials such as artificial spider silk, which exhibits remarkable mechanical properties and biocompatibility. The lab also explores the engineering of smart bacterial robots for therapeutic and biosensing purposes, aiming to create programmable biological systems for environmental and medical applications. Through interdisciplinary collaboration, the lab seeks to bridge fundamental research and real-world applications, providing a dynamic environment for international students to engage in innovative projects at the interface of biology, engineering, and materials science.


Research Topics
  • Synthetic Biology: cellular reprogramming, quorum sensing switch, biomedicine, biomolecular engineering
  • Metabolic engineering: autonomous protein expression systems, cellular pathway engineering, biotherapeutics production  
  • Biofabrication: bio-inspired assembly, bio-device interfaces, functional bio-conjugation, bio-nano integration 
  • Biomaterials: novel biomaterials, stimuli-responsive natural materials, biosensors, tissue engineering scaffolds

Honor
  • Gold Medal, 2024 iGEM competition: "Standardized AI-powered platform for carbon-sequestering spider silk production," National Taiwan University
  • Grand Prize, 2024 TGEM competition: "Standardized AI-powered platform for carbon-sequestering spider silk production," National Taiwan University
  • Organizer: 2021 conference in "Innovation and application in biological materials engineering," Agricultural Chemical Society of Taiwan
  • NSTC Grant for Recruiting Special Talents (2015-2018)
  • Multiple high-impact publications in internationally recognized journals, including Nature Nanotechnology , Nature Communications, and Advanced Functional Materials.
  • Recipient of research grants in the fields of synthetic biology, biomaterials, and biofabrication.

Educational Background
  • Ph.D. in Bioengineering, University of Maryland, College Park, USA (2012)
  • M.S. in Biology, Tunghai University, Taiwan (2002)
  • B.S. in Chemical Engineering, National Taiwan University, Taiwan (2000)

Job Description

  • Material Design: Design and synthesize recombinant spider silk-based hydrogels or fibrous scaffolds.
  • Biofabrication: Utilize techniques such as electrospinning, 3D bio-printing, or microfluidics to create structured bio-interfaces.
  • Characterization: Perform mechanical testing, surface functionalization analysis, and morphological characterization (e.g., SEM/Confocal microscopy).
  • Biological Validation: Conduct in vitro assays to evaluate biocompatibility and functional performance (e.g., antimicrobial efficacy or cell adhesion).
  • Documentation: Assist in data interpretation, modeling of genetic circuits, and drafting sections of scientific manuscripts.

Preferred Intern Educational Level

PhD Student (preferred) or Advanced Master’s Student in Bioengineering, Biomaterials, or Chemical Engineering.

Skill sets or Qualities

  • Technical Expertise: Strong background in biomaterials synthesis, specifically in hydrogels, scaffolds, or surface functionalization.
  • Laboratory Skills: Hands-on experience with material characterization tools and basic cell culture or microbiology techniques.
  • Data Analysis: Proficiency in scientific software such as OriginPro, GraphPad Prism, or ChemDraw.
  • Soft Skills: High level of motivation for interdisciplinary research, excellent problem-solving abilities, and strong written/oral communication skills in English.
  • Alignment: A keen interest in combining biology with engineering principles to solve real-world sustainability or medical challenges.