National Central University

Jun Lab

Yonggun Jun
https://sites.google.com/view/junlabtw

Research Field

Physics

Introduction

Professor Yonggun Jun is a professor in the Department of Physics at National Central University (NCU) in Taiwan. He leads the Cellular Biophysics and Nonequilibrium Physics Lab, where his work focuses on uncovering the fundamental physical laws that govern biological systems and small-scale non-equilibrium phenomena.

The Jun Lab is a research group dedicated to exploring the intersection of physics and biology. The lab's work is deeply rooted in the fields of Biophysics and Non-equilibrium Physics, focusing on how fundamental physical principles govern complex biological processes.

Core Research Areas

  • Stochastic Thermodynamics: The lab investigates the thermodynamics of small systems, including fluctuation theorems, Landauer's Principle, and the efficiency of microscopic heat engines.
  • Molecular Motors & Intracellular Transport: A primary focus is the mechanics of motor proteins like kinesin and dynein. The lab studies how these motors work together to transport cargo in the crowded environment of a cell.
  • Collective Behavior & Active Matter: Research includes the study of bacterial swarming, 2D turbulence, and the dynamics of active particles.

Lab Mission
The Jun Lab seeks to bridge the gap between equilibrium physics and biological processes. By applying rigorous physical frameworks to biological systems, the team aims to uncover the underlying mechanisms of life at the molecular and cellular levels.


Research Topics
  • Nonequilibrium thermodynamics
    • Microscopic heat engines
    • Optimal transport in overdamped and underdamped systems
  • Biological Physics
    • Intracellular transport by molecular motors
    • Bacterial dynamics
    • Active matters

Honor
  • 2021-2025 Outstanding Academic Research Award at National Central University (校學術研究傑出獎)
  • 2021     Excellent Teaching Award of Physics at the College of Science in National Central University
  • 2016     Award on NCU outstanding research for new employee (校傑出新聘教師)

Educational Background
  • Ph.D., Dept. of Physics and Astronomy, University of Pittsburgh, Pittsburgh (2001/9–2006/4)
  • M.S., Dept. of Physics, Pusan National University, Busan, Korea. (1997/3–1999/2)
  • B.S., Dept. of Physics, Pusan National University, Busan, Korea. (1990/2–1997/3)

Job Description

Study on stochastic thermodynamics

How do the laws of thermodynamics apply to a single molecule inside a cell, or a nanoparticle suspended in a vacuum? At the microscopic scale, "heat" is no longer just a temperature—it is a violent, random force that dominates everything.

Our lab explores Stochastic Thermodynamics, the branch of physics that explains how energy, work, and information behave under intense thermal fluctuations. We are recruiting motivated undergraduate or graduate interns to join us in investigating two distinct but deeply connected frontiers: Underdamped Optical Levitation and In Vitro Kinesin Dynamics.

1. The Underdamped Frontier: Optical Levitation
In a liquid, small particles are "overdamped"—friction is so high that inertia is ignored. But what happens when we remove the environment? By using a laser to levitate a nanoparticle in a high vacuum, we enter the underdamped regime.
Here, the particle acts as a high-precision harmonic oscillator. Because the damping is near zero, the particle’s inertia) becomes visible. This allows us to test:
-  The Fluctuation-Dissipation Theorem: Measuring how energy is exchanged between the particle and its sparse surroundings.
-  Information Engines: Testing if we can extract work from thermal noise (Maxwell’s Demon) in a system with memory and inertia.

2. The Biological Machine: Kinesin Dynamics
While levitated particles allow us to study fundamental physics in a "clean" vacuum, Kinesin allows us to study it in the "messy" complexity of life. Kinesins are biological molecular motors that convert chemical energy (ATP) into mechanical work by "walking" along microtubules.
We perform In Vitro experiments—reconstituting these motors outside the cell—to observe their dynamics. Using optical tweezers with sub-nanometer precision, we can:
-  Measure Stall Force: Determining the exact amount of force a single protein can exert against a load.
-  Analyze Step-by-Step Stochasticity: Every "step" a kinesin takes is a stochastic event. We use thermodynamics to understand the efficiency and "chemo-mechanical" coupling of these biological machines.

Why Join Our Lab?

As an intern, you won't just be a spectator; you will be an experimentalist. You will gain hands-on experience in:

  • Precision Optics: Aligning high-power lasers and optimizing optical traps (Optical Tweezers).
  • Vacuum Technology: Operating turbo-molecular pumps to reach the ultra-low pressures required for underdamped physics.
  • DIY Instrumentation: Using 3D printing and microcontrollers (like the ESP32) to build custom hardware for the experiment.
  • Computational Analysis: Using Python to perform spectral analysis and reconstruct the thermodynamic properties of the system from raw data.

 Who We Are Looking For

 We are seeking curious students with a background in Physics or Engineering who are:

1. Fascinated by how the "arrow of time" emerges from microscopic noise.
2. Interested in building things—whether it's an optical path or a data processing pipeline.
3. Eager to contribute to a lab that bridges nonequilibrium physics and advanced instrumentation.

Preferred Intern Educational Level

Master's, or undergraduate student

Skill sets or Qualities

Knowledge of thermal physics is required. Experimental skills such as Python and electronics may be required.