Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University

Protein trafficking

Chun-Chun Li
https://www.bio.ncku.edu.tw/english/faculty/prof-chun-chun-li

Research Field

Biology

Introduction

Dr. Li earned her Bachelor's degree in Biology from National Cheng Kung University in 2000 and obtained her Ph.D. in Molecular Medicine from National Taiwan University in 2007. From 2008 to 2013, she pursued postdoctoral research at the National Institutes of Health (NIH) in the United States. She is currently an Associate Professor in the Department of Life Sciences at National Cheng Kung University. Dr. Li’s research primarily focuses on vesicle trafficking, a fundamental process in cellular physiology. The precise coordination between vesicular transport and cytoskeletal remodeling is essential for key cellular functions, including biomolecule synthesis, secretion, endocytosis, and degradation. These processes play crucial roles in maintaining cell morphology, facilitating cell migration, supporting embryonic development, enabling immune surveillance, and promoting wound healing. Her research aims to elucidate the molecular mechanisms controlling regulated vesicular trafficking, particularly in the context of cell migration, development, metastasis, and chemoresistance.

Dysregulated vesicle trafficking has been implicated in various pathological conditions, including immune disorders, diabetes, neurodegenerative diseases, and cancer. Our laboratory investigates the molecular mechanisms underlying protein trafficking, with a particular focus on post-Golgi vesicular transport and cytoskeletal remodeling.


Research Topics

Research Interests

Small GTPases, such as ADP-ribosylation factors (Arfs) and their regulatory proteins, are believed to play pivotal roles in the regulation of vesicular trafficking and cytoskeletal remodeling. By integrating methodologies from cell biology, molecular biology, biochemistry, fluorescence microscopy, and proteomics, our research aims to elucidate the mechanisms by which Arfs and their regulators influence cell morphology, migration, development, and tumorigenesis.


Honor

2024  Award for Excellence in Tutoring, National Cheng Kung University
2022  Award for Excellence in Tutoring, National Cheng Kung University
2016  Award for Excellent teaching teachers, National Cheng Kung University


Educational Background

2000-2007  Ph.D., Institute of Molecular Medicine, National Taiwan University, Taiwan
1996-2000  B.S., Department of Life Sciences, National Cheng Kung University, Taiwan