Vaccine, Autoimmunity and Immunotherapy
Research Field
My research works focus on the following topics:
(1) Gene expression and signal transduction of inhibitory receptors: FcγRIIB, PD-1, PD-L1, etc.
(2) Autoimmune diseases, e.g. SLE.
(3) Vaccinology, germinal center reaction, T-dependent & T-independent vaccine-induced antibody responses.
(4) New cancer therapeutic targets, e.g. FcγRIIB, for drug development.
We address research questions using both in vitro assays and in vivo mouse models. Various FcγRIIB-associated mouse strains have been established to investigate the functional roles of FcγRIIB in health, e.g., vaccine-induced antibody response, and disease, including autoimmune diseases, infection and cancer. The ultimate goal is to develop FcγRIIB-based therapeutics for immunotherapy for diseases.
(1) Inhibitory Fc receptor and B-cell Immunology
(2) Vaccinology: germinal center reaction, affinity maturation, T-dependent & T-independent vaccine-induced antibody responses
(3) Autoimmune diseases: SLE and its pathogenesis and therapeutics
(4) Acute ischemic stroke and reperfusion injury
(5) Anti-tumor new drug development: FcγRIIB-based.
2018 Outstanding Medical Research Award, The Chinese Society of Immunology.
M.D. Department of Medicine, China Medical University, Taichung, Taiwan.
Ph.D. Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Illinois, U.S.A.
Job Description
Research projects on the inhibitory Fc receptor, i.e., FcγRIIB (the only inhibitory Fc receptor; a.k.a. CD32B), including immunization, autoimmune diseases and immunotherapy.
Preferred Intern Educational Level
College and master students.
Skill sets or Qualities
In vitro and in vivo experiments, in particular mouse experiments.
Job Description
Research projects on the inhibitory Fc receptor, i.e., FcγRIIB (the only inhibitory Fc receptor; a.k.a. CD32B), including immunization, autoimmune diseases and immunotherapy.
Preferred Intern Educational Level
College and master student
Skill sets or Qualities
In vitro and in vivo experiments, in particular mouse experiments.