National Chung Cheng University

NMR/MRI Lab

Eugene C. Lin
https://lineclab.wordpress.com/

Research Field

Chemistry

Introduction

Dr. Eugene C. Lin is an accomplished researcher and educator in the field of chemistry and biochemistry. Currently serving as an associate professor at the Department of Chemistry and Biochemistry, National Chung Cheng University, Eugene’s academic journey spans continents—from earning his Ph.D. in Chemistry and Biochemistry at the University of California, San Diego to his subsequent postdoctoral research at Vanderbilt University Medical Center. His expertise lies in bioimaging and spectroscopic techniques with a special focus on molecular imaging methods that bridge the gap between chemical analysis and clinical applications. With a passion for innovative teaching and mentorship, Eugene has developed engaging courses (including biophysical chemistry) and has guided numerous graduate and undergraduate students to success in both research and competitive forums.

The laboratory under Dr. Lin's leadership is dedicated to advancing the emerging field of radiometabolomics—a discipline that integrates metabolic spectroscopy, magnetic resonance imaging (MRI), and quantitative statistical analysis to unravel biological and clinical phenomena at the molecular level. The lab is at the forefront of developing novel imaging techniques, such as cholesterol‐weighted MRI and chemical exchange saturation transfer (CEST) methods, that capture subtle metabolic variations in tissues. By designing innovative in vitro platforms (including three‐dimensional cell spheroid systems) and refining extraction protocols for cells, spheroids, and tissues, the group not only pushes the boundaries of imaging science but also lays the groundwork for more precise disease classification and diagnosis.


Research Topics

Lab Specialization: Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) techniques.
Main Focus: Development and application of Chemical Exchange Saturation Transfer (CEST) MRI contrast agents.
CEST Mechanism: Detects proton exchange between solutes (e.g., metabolites, lipids) and water, enabling non-invasive imaging of molecular concentrations and tissue pH without external contrast agents.
Innovative Validation Platform: Living cells embedded in methylcellulose hydrogels for simultaneous NMR spectra and CEST measurements, mimicking real biological conditions.
Emerging Direction: Deep Eutectic Solvents (DES) as green, tunable systems for CEST studies and novel contrast enhancement in molecular imaging.


Honor

2022 Taiwan Comprehensive University System Young Scholars Award for Innovative R&D

2023 National Chung Cheng University Young Scholar Award


Educational Background

B.S. in Applied Chemistry, National Chi Nan University, 2006

M.S. in Chemistry, National Chung Hsing University, 2008

Ph.D in Chemistry and Biochemistry, University of California, San Diego, 2015

Postdoc Fellow, Vanderbilt University Institute of Imaging Science, 2015-2018