Taipei Medical University

Lane Lab

Lucas Lane
https://hub.tmu.edu.tw/en/persons/lucas-lane/

Research Field

Medical Engineering

Introduction

Lucas Lane is an Assistant Professor at Taipei Medical University (TMU), specializing in Biomedical Engineering, particularly in nanobiosensing and stimuli-responsive nanocarriers, and holds a Ph.D. from Georgia Tech. He is a member of TMU's International Ph.D. Program in Biomedical Engineering and Graduate Institutes of Biomedical Optomechatronics.  

My research focuses on the development and clinical translation of optical-based biomedical technologies. Current projects in my laboratory include using surface-enhanced Raman scattering (SERS) and fluorescence techniques for image-guided surgery, quantitative diagnostics, and the study of cancer pathophysiology. Above all, I aim to make scientific contributions that increase survival rates and improve the quality of life for patients struggling with complex diseases.


Research Topics
  • Using SERS nanotags as probes to investigate optimal parameters in nanomedicine design
  • Using SERS nanotags to detect rare cancer cells in complex biological solutions
  • Using biomimetic coatings to increase the delivery and uptake of nanomedicines and optical imaging probes

Honor

            Distinguished Professorship, "Lifenergy Scholar", Nanjing University 2017

            Selected as part of the 13th batch in China's National 1000 Global Talents Project 2017

            Best Poster Presentation, Institute for Electronics and Nanotechnology at Georgia Tech 2013

            2nd Place Student Paper Competition, American Institute of Chemical Engineers 2009


Educational Background

Georgia Institute of Technology, Ph.D. in Bioengineering, 2014

Dissertation title: Advancement of Blinking Suppressed Quantum Dots for Enhanced Single Molecule Imaging

Minor: Nonlinear and Applied Mathematics

Thesis Committee: Shuming Nie (Advisor). Younan Xia, Mostafa El-Sayed, Gang Bao, Adam Marcus

Washington University in St. Louis, B.S. in Applied Science, 2009


Job Description

The intern will synthesize gold nanoparticles of different shapes and sizes. Culture various cells and extract their membranes for use as nanoparticle coatings. Apply the optical probes to various cell cultures to analyze specific binding and uptake over time. Use in vivo tumor models to determine which constructs have optimal circulation and tumor-targeting characteristics.  Use SERS techniques to analyze multiple particle constructions in a single setting.  

Preferred Intern Educational Level

Preference is for students to have a background in the physical and chemical sciences, along with some previous experience in chemical synthesis techniques, optical imaging, and dealing with cells or animal models. 

Skill sets or Qualities

Familiar with the synthesis of inorganic nanoparticles

Cell culture

Familiar with basic optical principles

Job Description

Using the software package COMSOL to calculate electric field enhancements and the extinction, scattering, and absorption properties of various particle configurations.

Preferred Intern Educational Level

Undergraduate with experience in calculus and differential equations. Preferred experience with computational techniques and classes that solve partial differential equations analytically, along with classes in optics, electromagnetics, or both.

Skill sets or Qualities

Mathematical ability at the level of differential equations

Familiarity with Finite element methods

Familiarity or had courses in electromagnetics and optics