Academia Sinica

Pattern Formation Lab

Jian-geng Chiou
https://jchioulab.github.io/landing.html

Research Field

Emerging/Other Fields

Introduction

A self-proclaimed biologist when I need an excuse for being bad at physics. A self-proclaimed physicist when I honestly can’t remember that many genes.
I went to Duke University to pursue my PhD and origianlly my interest in evolution and development (evo-devo). Less than a year later, I ditched my original interest and studies how a budding yeast bud. That question accidentally became a physics problem of how certain proteins autonomously pattern in the yeast cell. Before I realized, I was attending more physics meetings than biology ones. After graduation, I went to do a postdoc in UCSD. Having the advantage of (moderately) knowing both biology and physics, I published barely enough to start my own lab in the Institute of Plant and Molecular Biology (IPMB) in Academia Sinica, Taiwan. I now plan to answer fundamentally evo-devos question using biophysics approaches.

Pattern formation is a fascinating process critical in the development of multicellular organisms. Although the underlying molecular pathways for pattern formation may be completely different between distinct phylogenetic clades, they often follow similar mathematical principles. Since mathematical principles often transcend taxonomic boundaries, why can't patterning also occur in 'unicellular' microbes? We use interdisciplinary approaches, including live cell microscopy and mathematical modeling to studies the principles of pattern formation that play key roles in microbial developmental processes.


Research Topics

Cell polarity

How does the same polarity machinery result in diverse growth modes? The answer lies within the intra-cellular pattern formation process of polarity proteins. We explore how the recently developed Turing theoretical framework could explain cell polarity modes in not only the budding yeast but also the diversity of growth modes among Ascomycete fungi. We are also trying to build the yeast polarity machinery synthetically into plants as orthogonal systems. In the attempt, we will get to engineer our version of the polarity circuit according to our theoretical framework, without the constraints of the yeast physiology and size limitations. If we succeed, we will unlock the ability to modulate plant development.


Honor

Emerging Young Scholar | 2030 CROSS-GENERATION YOUNG SCHOLARS PROGRAM, MINISTRY OF SCIENCE AND TECHNOLOGY, TAIWAN
 


Educational Background

Ph.D., Genetics and Genomics, Duke University


Job Description

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Preferred Intern Educational Level

Undergraduates.

Skill sets or Qualities

Familiarity with simulations of ordinary or partial differential systems. Familiarity with molecular biology and cell biology. Motivation and Curiosity.