National Dong Hwa University

Bioanalytical Mass Spectrometry Lab

Cheng-Kang Chiang
https://sys.ndhu.edu.tw/RD/TeacherTreasury/tlist.aspx?nav=0&tcher=12808

Research Field

Chemistry

Introduction

I am Cheng-Kang Chiang, currently serving as an Associate Professor in the Department of Chemistry at National Dong Hwa University (NDHU). I received my Ph.D. in Chemistry from National Taiwan University in 2010. Following the completion of my doctoral degree, I pursued postdoctoral training at the Ottawa Institute of Systems Biology, University of Ottawa, and at the Children's Hospital of Eastern Ontario in Canada. In 2017, I joined the Department of Chemistry at NDHU, where I currently hold the position of Associate Professor.

With the rapid advancement of nanotechnology, the synthesis of functional nanomaterials (NMs) and the exploration of their potential chemical and biomedical applications have become major highlights in scientific development over the past two decades. In parallel, the application of green chemistry principles for the fabrication of nanoscale materials has attracted extensive attention from the scientific community over the last decade. Our laboratory focuses on the green synthesis of nanomaterials by employing traditional medicinal herbs as bioresources. After extracting their principal bioactive constituents, we utilize these phytochemicals as reducing and stabilizing agents to fabricate broad-spectrum antibacterial nanomaterials with enhanced antimicrobial efficacy. Furthermore, we apply high-resolution mass spectrometry–based approaches to investigate the adaptive and survival mechanisms of bacteria under nanomaterial-induced stress. In addition, we are currently developing spatial mass spectrometry technologies to elucidate the biodistribution and tissue penetration pathways of toxic molecules, thereby advancing our understanding of how these compounds enter the human body and subsequently impact human health.


Research Topics

(1)Green synthesis of bioactive metallic nanomaterials with enhanced antibacterial efficacy, and elucidation of their antimicrobial mechanisms using mass spectrometry–based approaches.

(2)Development of toxin-imaging mass spectrometry techniques to investigate how pesticides alter metabolite distributions within the human microenvironment.

(3)Application of supercritical fluid chromatography (SFC) coupled with metal catalysis for the degradation of persistent organic pollutants (POPs) in solid matrices.


Honor

Award of HUPO 2016 Early Career Researcher Manuscript Competition, first place (2016)


Educational Background

Children's Hospital of Eastern Ontario Postdoctoral Fellow (2016/9~2017/1)

University of Ottawa Ottawa Institute of Systems Biology Postdoctoral Fellow (2011/9~2016/8)


Job Description

Students will have the opportunity to participate in interdisciplinary projects involving green nanomaterial synthesis, antimicrobial mechanism studies using advanced mass spectrometry, and the development of spatial mass spectrometry techniques for investigating the biodistribution of toxic compounds. Through this experience, participants will gain hands-on training, develop critical research skills, and contribute to cutting-edge studies at the interface of chemistry and biomedicine.

Preferred Intern Educational Level

To support these research efforts, we warmly invite undergraduate and master’s students with interests in chemistry, biomedical science, or related fields to join our laboratory. Applicants should possess strong communication skills and the ability to work effectively in a team environment, along with a solid foundation in chemistry. Prior knowledge or experience in pharmaceutical sciences, biomedical research, or traditional herbal medicine will be considered an advantage.

Skill sets or Qualities

Applicants should possess strong communication skills and the ability to work effectively in a team environment. A solid background in chemistry is required, and familiarity with pharmaceutical sciences, biomedical research, or traditional herbal medicine will be considered an advantage.