Taipei Medical University

Silk Protein Based Biomaterials

Jen-Chang Yang
https://hub.tmu.edu.tw/zh/persons/jen-chang-yang

Research Field

Materials Engineering

Introduction

Jen-Chang Yang is a professor at the Graduate Institute of Nanomedicine and Medical Engineering at Taipei Medical University and a joint-appointment professor at the School of Dentistry, the International Ph.D. Program in Biomedical Engineering and, the TMU Research Center of Biomedical Devices. He has a Ph.D. in Polymer Engineering from the University of Akron, USAHe has been working at Taipei Medical University since 2007 and has served as the vice dean of the College of Biomedical Engineering since 2019His research interests include oral biomaterials, medical devices, silk protein, biomimetic materials, bioceramics, nanofiber technology, ionotronic hydrogels, and weight management hydrogels. He has published more than 100 research papers and participated in many nanomedicine and biomedical engineering projects

Prof. Jen-Chang Yang (H=18) majors in the fields of regenerative medicine as well as dental
materials. He is also an expert in the regulation of materials to stem cell fate. Synthesis of
bioceramics and nanomaterials will be performed in the Graduate Institute of Nanomedicine and
Medical Engineering, College of Biomedical Engineering, Taipei Medical University. The scientific
expertise of this department in the preparation of nanomaterials with silk fibroin (SF) and its
derivatives is very high. The sonoelectrochemistry process of preparing the oxidized SF nanofibrils
without dialysis is unique. Also, the laboratories of this department are equipped with a modern
technique for the characterization of materials obtained by Mastersizer 3000, Rheometer
(Anton Paar), contact angle, and microhardness tester. The XRD, SEM, TG/DTA, and AFM
measurements will be performed in the Department of Chemical Engineering and Biotechnology.
This laboratory will also conduct the ISO 10993 biocompatibility and in vivo study of novel injectable cement. Both FTIR microscopes and Raman microscopes are available for
micro-region material characterization. The physicochemical properties of injectable cement-like
setting time, radiopacity, injectability, and diametral tensile strength (DTS) will be investigated
using Vicat needle, dental X-ray system, dynamic contact angle, and texture profile analyzer (TPA),
respectively. For the evaluations of cell/ molecular biology, Yang’s team has a cell incubator, clean
bench, spectrophotometer, RT-PCR, q-PCR, inverted fluorescence microscope, western blot
system, and iBright imaging systems, which can be used to analyze the influences of prepared
nanomaterials to cells.


Research Topics

I. Medical Devices for Obesity Treatment

II. Silk-Derived Protein for Dry Eyes Diseases

III. Silk Fibroin Based Anti-Bleeding Hydrogel

Recent Publications: 

  • Lu, P. W., Wu, Y. T., Chang, L. Y., Lu, T. W., Jaihao, C., Huang, C. S., ... & Yang, J. C. (2023). The biocompatibility and hemostatic efficacy of silk fibroin nanofibrils fabricated by Shear-Induced phase separation process. Chemical Engineering Journal, 474, 145731.
  • Lu, P. W., Jaihao, C., Pan, L. C., Tsai, P. W., Huang, C. S., Brangule, A., Zarkov, A., Kareiva, A., Wang, H. T., & Yang, J. C. (2022). The Processing and Electrical Properties of Isotactic Polypropylene/Copper Nanowire Composites. Polymers, 14(16), 3369.
  • Wu, Y. T., Lu, P. W., Lin, C. A., Chang, L. Y., Jaihao, C., Peng, T. Y., ... & Yang, J. C. (2023). Development of a zinc chloride-based chemo-mechanical system for a potential minimally invasive dental caries removal system. Journal of Dental Sciences.
  • Hao P-C, Burnouf T, Chiang C-W, Jheng P-R, Szunerits S, Yang J-C, et al. Enhanced diabetic wound healing using platelet-derived extracellular vesicles and reduced graphene oxide in polymer-coordinated hydrogels. Journal of Nanobiotechnology 2023;21(1):318.
  • Kizalaite A, Klimavicius V, Balevicius V, Niaura G, Salak AN, Yang J-C, et al. Dissolution–precipitation synthesis and thermal stability of magnesium whitlockite. CrystEngComm 2023;25(30):4370-4379.
  • B. Y. Bhardwaj, S. Vihal, R. Pahwa, S. Agarwal, B. Gupta, J. C. Yang, et al., Recent advancements in xanthan gum-based gastroretentive floating formulations: Chemical modification, production and applications, Carbohydrate Polymers 2025 Vol. 348 Pages 122809

Honor

2025 "National Innovation Award" for "Stress-Induced Phase-Separated Calcium Ion-Type Silk Fibroin Nanofiber as an Innovative Hemostatic Material," recognizing contributions to innovative hemostatic materials.


Educational Background
  • Ph.D. in Polymer Engineering, University of Akron (USA), 1992                                                                                                               
  • M.S. in Polymer Engineering, University of Akron (USA), 1989
  • B.S. in Chemical Engineering, Tunghai University (Taiwan), 1983

Job Description

  • patent searching and analysis related with the current commercial weight management medice devices 

Preferred Intern Educational Level

Undergraduate or master student with basic chemistry and biopolymer background.

Skill sets or Qualities

  • basic chemistry handling experience
  • FTIR, XRD, DSC experience
  • DOE (design of experiment)