National Research Institute of Chinese Medicine

Wen-Tai Li

Wen-Tai Li
https://www.nricm.edu.tw/p/406-1000-2255,r65.php?Lang=zh-tw

Research Field

Chemistry

Introduction

Wen-Tai Li received his Ph.D. in Chemistry from National Tsing Hua University in 1999, specializing in organometallic chemistry. He joined the National Research Institute of Chinese Medicine (NRICM), Ministry of Health and Welfare, Taiwan, in the summer of 2011, where he currently serves as a Research Fellow. His primary research focuses on the development of new synthetic methodologies and transition-metal-catalyzed strategies for the synthesis of bioactive molecules. In addition, his research interests include the design of fluorescent probes and photoaffinity-labeling probes for selective cancer cell visualization and intracellular target protein identification.

Our current research focuses on medicinal chemistry, synthetic organic and organometallic chemistry, and phytochemistry. Major research topics include the development of novel and efficient synthetic methodologies, the design and synthesis of biologically active molecules, and the synthesis of natural products derived from traditional Chinese medicine. In particular, our work emphasizes transition-metal-catalyzed reactions for the construction of bioactive molecules. In addition, we are developing fluorescent probes and photoaffinity-labeling probes to enable selective cancer cell visualization and intracellular target protein identification.


Research Topics

Our research focuses on the development of novel and efficient synthetic methodologies, the design and synthesis of biologically active molecules, and the synthesis of natural products derived from traditional Chinese medicine. The following research directions are currently being pursued:

Development of microwave-assisted and metal-catalyzed synthetic approaches for the construction of chromone and benzoxanthone derivatives.

Design and synthesis of novel small-molecule inhibitors targeting Cdk5/p25, MAO-B, and amyloid-β aggregation.

Development of PROTAC-based strategies for targeted cancer therapy.

Design of fluorescent probes and photoaffinity-labeling probes for selective cancer cell visualization and intracellular target protein identification.


Honor

2018 International Innovation and Invention Competition (Gold medal)


Educational Background

Ph.D. degree in chemistry from National Tsing Hua University

Postdotoral research in chemistry at Ohio-State university and University of Texas at austin.


Job Description

The organic chemistry research intern is a hands-on role, involved in organic/organometallic/medicinal chemistry research to support the development of novel small molecule therapeutics.

Preferred Intern Educational Level

Applicants must currently be enrolled as undergraduate or graduate students majoring in chemistry or a closely related discipline. They should have successfully completed a minimum of three full years of college-level chemistry coursework, including the corresponding laboratory sections.

Skill sets or Qualities

  • Strong communication skills (written and spoken English) with excellent organizational ability
  • Self-starter who is results-oriented, resourceful, analytical, innovative, intellectually curious, and proactive
  • Highly organized and meticulous, with strong documentation and record-keeping skills
  • Basic laboratory skills in organic chemistry, including extraction, purification, and routine handling of organic compounds